| 张丽红1 齐蕾2 单丽辉2 柴翠翠2 韩伟2 王立峰2.人脑星形细胞瘤中p53，Fas/FasL 的表达及其与凋亡关系的研究[J].现代生物医学进展英文版,2011,11(18):3501-3503. |
| 人脑星形细胞瘤中p53，Fas/FasL 的表达及其与凋亡关系的研究 |
| The expression of p53, Fas /FasL and their correlation with apoptosisin human brain astrocytomas |
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| DOI： |
| 中文关键词: 星形细胞瘤 细胞凋亡 p53 Fas/FasL |
| 英文关键词: Astrocytoma Apoptosis p53 Fas/FasL |
| 基金项目:哈尔滨市科技创新人才专项资金项目（RC2010XK004048） |
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| 中文摘要: |
| 目的：探讨细胞凋亡在星形细胞瘤中的作用及其与p53、Fas 和Fas 配体(Fas ligand, FasL)的关系。方法：对43 例星形细胞瘤
的标本分别进行HE 染色，TUNEL 及免疫组化分别标记p53，Fas 和FasL。结果：高级别肿瘤和低级别肿瘤间的凋亡无显著差异
（P>0.05）。高级别星形细胞瘤的p53，Fas 和FasL 的表达均显著高于低级别肿瘤（P 均<0.05）。结论：突变型p53 可作为评价星形
细胞瘤生物学行为的参考指标。与低级别星形细胞瘤相比，高级别肿瘤中的细胞凋亡受到了抑制，且Fas 与FasL 的过表达对细胞
凋亡可产生明显影响。 |
| 英文摘要: |
| Objective: To investigate the role of apoptosis in the progression of astrocytomas and its correlation with the expression
of p53 and Fas/FasL. Methods: Histopathological analysis, TUNEL labeling and immunohistochemical staining of p53 and Fas/FasL.
Results: Apoptosis was not significantly different in the two groups（P>0.05）; Expression of p53, Fas and FasL was significantly higher in
the high-grade astrocytomas than the low-grade ones (P<0.05). Conclusion: p53 can serve as an informative parameter to evaluate the
biological behavior of astrocytomas, Apoptosis may be |
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