| 杜心佳1 刘希光2.E-cad、EGFR、MMP9 与肺癌转移的关系[J].现代生物医学进展英文版,2011,11(18):3480-3484. |
| E-cad、EGFR、MMP9 与肺癌转移的关系 |
| E-cad、EGFR、MMP9 与肺癌转移的关系 |
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| DOI： |
| 中文关键词: 上皮型钙粘附蛋白 表皮生长因子受体 金属基质酶9 早转移非小细胞肺癌 |
| 英文关键词: E-cadherin Epidermal growth factor receptor Matrix metalloproteinase-9 Early transferred Non-small cell lung cancer |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨原发性非小细胞肺癌(NSCLC)组织中E- 钙粘蛋白(E-cadherin,E-cad)、表皮生长因子受体(Epidermal Growth Factor
Receptor，EGFR)和基质金属蛋白酶9(matrix metalloproteinase-9,MMP9)的表达与术后复发及转移的关系。方法：选择临床IB 期非
小细胞肺癌患者的手术切除标本，其中36 例于36 个月之内发生复发或转移，30 例术后无病生存期超过36 个月。采用免疫组织
化学方法检测组织中E-cad、EGFR、MMP9 的表达情况。结果：36 例早转移IB 期非小细胞肺癌术后患者的手术标本中，E-cad 的异
常表达率、EGFR 及MMP9 的阳性表达率，均明显高于30 例非早转移IB 期非小细胞肺癌术后患者（P<0.05），且在早转移IB 期
NSCLC 中，三者的表达与病理分级、肿瘤大小有关（P<0.05），与病理类型，肿瘤是否浸润胸膜无关（P>0.05）。结论：对早期肺癌术
后病人，检测E-cad、EGFR、MMP9 的表达，对判断其恶性程度，提示肿瘤的复发及转移倾向大小，决定术后治疗方案有重要意义。 |
| 英文摘要: |
| Objective: To study clinical relationship between the expression of E-cadherin(E-cad), epidermal growth factor receptor
(EGFR), matrix metalloproteinase-9（MMP9）and postoperative recurrence and distant metastasis in patients with non-small lung cancer
(NSCLC). Method: Immuno-- histochemical method (SP) was used to detect the expression of the E-cad, EGFR, MMP9 in 36 IB stage
NSCLC tissues which had transferred within 3 year after operation and 30 IB stage NSCLC tissues which hadn't transferred within 3
year after operation. Result: The positive expression rates of EGFR、MMP9 and the abnormal expression rates of E-cad in the early
transferred IB stage NSCLC were higher than those in the non-early transferred IB stage NSCLC （P<0.05）. Significant difference of
the expression level of the E-cad, EGFR, MMP9 in early transferred IB stage NSCLC was found between different pathological grades
and different tumor size （P<0.05）. There was no significant correlation between E-cad, EGFR or MMP9 expression and pathological
type or whether infiltrating pleural ( P>0.05). Conclusion: Examination of expression levels of the E-cad, EGFR and MMP9 was of
significance in malignant potential 、prognosis and treatment of early NSCLC. |
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