| 王静侯旭孙新华.CpG ODN 对破骨细胞分化调控作用的研究进展[J].现代生物医学进展英文版,2011,11(17):3390-3392. |
| CpG ODN 对破骨细胞分化调控作用的研究进展 |
| The Current Studies about the Regulation Effect of CpGOligodeoxynucleotides on Osteoclast Differentiation |
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| DOI： |
| 中文关键词: CpG 寡脱氧核苷酸 破骨细胞 分化 Toll 样受体9 |
| 英文关键词: CpG oligodeoxynucleotides Osteoclastogenesis Differentiation Toll-like receptors 9 |
| 基金项目:吉林省自然科学基金（201015203） |
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| 中文摘要: |
| CpG ODN(CpG oligodeoxynucleotides)是一类可模拟细菌DNA 免疫活性效应的寡脱氧核苷酸，其生物学功能受自身结构特
征影响。特定序列的CpG ODN 可通过与破骨细胞前体、前破骨细胞、成骨细胞表面的TLR9 结合，调节RANKL、M-CSF、TNF-a、
IL-12、TREM-2 等细胞因子的表达水平，促进或抑制破骨细胞的形成与分化。本文就CpG ODN 对破骨细胞(osteoclast, OC)分化调
控作用的研究进展加以综述。 |
| 英文摘要: |
| CpG ODN is a kind of oligodeoxynucleotides which simulate the immune activity effect of bacterial DNA. Its biological
function is decided by its structure characteristics.Specific CpG ODN can stimulate or inhibit the osteoclastogenesis via the toll-like
receptors 9 of OC precursors ,pre-osteoclasts and Osteoblasts by adjusting the level of RANKL,M-CSF, TNF-a, IL-12, TREM-2. The paper
reviews introduces current studies about CpG oligodeoxynucleotides and its regulation effect on osteoclast differentiation. |
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