| 杨泽艳吴素凤蒋淑珍.早期干预对早产儿脑损伤预后的临床观察[J].现代生物医学进展英文版,2011,11(17):3342-3345. |
| 早期干预对早产儿脑损伤预后的临床观察 |
| Clinical Research on Early Intervention to Prognosis of Premature Infantswith Brain Damage |
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| DOI： |
| 中文关键词: 早产儿 脑损伤 联合干预 神经节苷脂 预后 |
| 英文关键词: Premature infant Brain damage Early intervention Ganglioside GM-1 Prognosis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨早期联合干预对脑损伤早产儿智能及运动发育的影响。方法：80 例存在脑损伤的早产儿随机分为干预组与对照
组，每组各40 例，对照组给予常规治疗与保健指导，干预组在此基础上联合神经节苷脂治疗与早期康复训练，定期随访两年，观
察比较患儿纠正胎龄40 周时神经行为评分（NBNA），智力及运动发育情况。结果：干预组患儿纠正胎龄40 周NBNA 评分为
33.04±1.12，对照组NBNA 评分为30.95±0.88，两组间差异有统计学意义（P<0.05）；干预组MDI 与PDI 指数分别于9 月龄始和
6 月龄始显著高于对照组（P<0.01 或0.05）；1 岁时进行Gesell 智力发育检查，干预组大运动、精细动作、适应性、语言、个人－社会
交往等五个能区情况均明显好于对照组（P<0.01）；干预组17.5%的后遗症发生率显著低于对照组32.5%的发生率（P<0.01）。结
论：联合早期干预治疗可有效促进脑损伤早产儿神经系统功能修复，改善智能及运动发育，减少后遗症发生。 |
| 英文摘要: |
| Objective: To explore the clinical effects of early comprehensive intervention on development of intelligence and
motor in preterm infants with brain injury. Methods: 80 infants with brain damage were divided into two groups, the control group (n=40)
received conventional therapy and health care instruction, and the intervention group (n=40) also received early synthesis intervention
(GM-1+rehabilitation training). The infants in both groups were followed up regularly for 2 years, and were examined neonatal
behavioral neurological assessments (NBNA) in the correction age of the 40 weeks, as well as the development assessments of
intelligence and motor. Results: The difference of NBNA scores in the correction age of 40 weeks between the control group (30.95±
0.88) and the intervention group (33.04±1.12) had statistical significance (P<0.05); the mental development index (MDI) of 9 months
old infants and the physical development index (PDI) of 6 months old infants in intervention group were significantly higher than those in
control group (P<0.05 or P<0.01); when the infants were 1 year old, there were significant differences in gross motor, fine motor,
adaptive, language and personal-social function areas between the two groups, especially better in the intervention group (P<0.01); The
sequelae rate of the intervention groups (17.5%) were less than that of the control group (32.5%) (P<0.01). Conclusion: The early
comprehensive intervention may obviously rehabilitate the damaged neurological system of premature infants with brain injury, promote
the development of intelligence and motor and reduce the rate of disability. |
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