| 李成谷青刘新孙明伟王充强.肝硬化患者肝脏门静脉血流与肝叶萎缩之间关系的研究[J].现代生物医学进展英文版,2011,11(17):3311-3314. |
| 肝硬化患者肝脏门静脉血流与肝叶萎缩之间关系的研究 |
| The Relation Between Heptic Lobes Atrophy and Portal Vein Flow |
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| DOI： |
| 中文关键词: 肝硬化，多普勒超声，门静脉 |
| 英文关键词: Hepatic cirrhosis Doppler ultrasound Portal vein |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨肝硬化患者肝脏右叶、左叶体积变化，检测肝硬化患者门静脉血流情况，分析二者之间的关系，以及门静脉血流
与肝功能之间关系。方法：本研究纳入54 例肝硬化患者和40 例正常人，采用超声多普勒方法分析这些受试者的肝脏体积和门静
脉主干及左右分支的内径、血流速、流量数据，并通过静脉血检测白蛋白、胆红素、胆碱酯酶水平等评估患者肝功能水平。结果：肝
硬化组平均年龄46.3 岁，男性32 例，其中child A 级患者16 例，child B 级患者27 例，child C 级患者11 例；正常对照组平均年龄
41.8 岁，男性24 例。肝硬化组患者右左肝叶之比明显低于正常对照组(p<0.05)，门静脉内径和血流量明显高于正常对照组(p<0.
05). 随着child 分级升高，门静脉血流量也明显升高。肝硬化组门静脉右支血流量明显低于左支血流量(p<0.05)；此外肝硬化患者
门静脉右支和左支血流量之比明显低于正常人群门静脉右左支之比(p<0.05)；而且肝硬化患者门静脉右左支血流量之比与右左肝
叶具有明显的相关性与右左肝叶之比具有明显的相关性（r=0.64，p<0.05）。结论：评估肝硬化病人门静脉血流情况，对于判断肝脏
病理变化程度，评价治疗效果，以及选择治疗方案方面都具有重要的临床价值 |
| 英文摘要: |
| Objective: To evaluate the lobe variety of hepatic cirrhosis, investigate the blood flow of Portal Vein, and analyze the
relation between the Portal Vein and hepatic lobes. Methods: 54 patients with hepatic cirrhosis and 40 normal controls were enrolled the
study. For all the subjects, the hepatic lobes volume, the portal vein flow, portal vein inner diameter and portal vein blood velocity was
evaluated by Doppler ultrasound; and the plasma albumin, bilirubin, acetylcholine esterase were investigated to evaluate the liver function.
Results: In the liver cirrhosis group, the mean age of patients was 46.3, and 32 was male; and in these patients, 16 was in Child A, 27 was
in Child B, and 11 was in Child C. For the normal controls, the mean age was 41.8, and 24 was male. In the liver cirrhosis, the the ratio of
right lobe to left lobe was much lower than the ration in the controls (p<0.05), the portal vein inner diameter and blood flow both were
significantly higher than the controls, respectively (p<0.05). With the Child classification increased, the portal vein blood flow increased,
accordingly. In the portal vein blood flow of the liver cirrhosis, the right branch was significant lower than the left branch(p<0.05).
Besides, the ratio of right-left branch flow of liver cirrhosis was much lower than the ratio in the normal controls(p<0.05). In the liver cirrhosis
group, the ratio of right-left branch flow was significant correlated with ratio of right-left liver lobe (r=0.64，p<0.05). Conclusion:
The evaluation of liver portal vein would benefit to the prognosis of liver cirrhosis and treatment effectiveness. |
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