| 齐天伟1 张超2 孙学峰1.食管鳞癌与腺癌差异基因表达的对比分析[J].现代生物医学进展英文版,2011,11(17):3293-3295. |
| 食管鳞癌与腺癌差异基因表达的对比分析 |
| Differences of Gene Expression Profile between Esophageal SquamousCell Carcinoma and Esophageal Adenocarcinoma |
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| DOI： |
| 中文关键词: 食管鳞癌 食管腺癌 基因表达 基因芯片分析 |
| 英文关键词: Esophageal squamous cell carcinoma Esophageal adenocarcinoma Gene expression Gene chip analysis |
| 基金项目:深圳市基础研究计划（JC201005260215A） |
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| 中文摘要: |
| 目的：研究食管鳞癌(esophageal squamous cell carcinoma，ESCC)与食管腺癌(esophageal adenocarcinoma, EAC)的基因差异表
达，探讨ESCC 与EAC 发生发展的基因学基础。方法：选取8 例ESCC 和8 例EAC 组织抽提mRNA，应用cDNA 芯片技术通过
芯片杂交、生物信息学处理，找出两者间差异表达基因。结果：采用BioStarH-40 芯片发现差异表达基因541 条，差异表达基因占
13.8％，其中表达增强309 条(显著增强73 条)，表达降低232 条(显著降低61 条)。结论：ESCC 与EAC 基因表达比较，差异有统
计学意义，这些差异可能在两类肿瘤不同的生物学行为中起重要作用。 |
| 英文摘要: |
| Objective: To determine the diference in the gene expression between human esophageal squamous cell carcinoma
(ESCC) and esophageal adenocarcinoma (EAC). Methods: cDNA chip was used to detect the mRNA of cancer tissue from 8 ESCCs and
8 EACs. After profile bloted and handled by bioinformation,the gene expression of these two kinds of lesions was examined. Results:
Using the BioStarH-40 profile，541 diferent expression of genes was found. The rate of different genes was 13.8%, of which the exprssion
of 309 genes increased (73 genes significantly increased) and 232 genes decreased (61 genes significantly decreased ) in ESCC tissue
than that in EAC. Conclusions: The gene expression of ESCC and EAC was different, which may contribute to the different biological
behavior of these two kinds of esophageal cancer. |
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