| 廖清池周胜华.microRNA 生物合成的调控进展--TGFβ/Smad 信号途径的作用[J].现代生物医学进展英文版,2011,11(14):2779-2782. |
| microRNA 生物合成的调控进展--TGFβ/Smad 信号途径的作用 |
| Progress of Regulating MicroRNA Biogenesis by TGF-β/SmadSignaling Pathway |
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| DOI： |
| 中文关键词: MicroRNA Smad Drosha 酶 |
| 英文关键词: MicroRNA Smad Drosha 酶 |
| 基金项目:国家自然科学基金（30871053） |
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| 中文摘要: |
| microRNA(miRNA)是一类非编码的小分子单链RNA，主要通过转录后抑制靶基因表达调节各种生物功能。miRNA 表达水
平在正常发育过程中以及在癌症及心血管疾病等各种疾病中发生变化。目前控制miRNA 生物合成的信号途径以及调节机制尚
未完全阐明。miRNA 基因转录后在大蛋白复合体的介导下经一系列协调加工过程形成成熟的miRNA。近来发现转化生长因子β
（TGFβ）信号途径的转导因子Smad 蛋白在细胞核内调节miRNA 的加工处理过程起重要作用。本文主要综述TGFβ/Smad 信号途
径在miRNA 生物合成中的调节作用。 |
| 英文摘要: |
| MicroRNAs (miRNAs) are small, non-coding and single-strand RNAs which modulate diverse biological function
through post-translational repression of target gene expression. The levels of miRNAs are altered during normal development and pathogenesis
of various diseases, including cancer and cardiovascular diseases. However, the signaling pathway controlling miRNA biogenesis
and the regulating mechanism are not fully elucidated. Following transcription, mature miRNAs are produced through a series of coordinated
processes mediated by large protein complexes. Recently the Smads, the signal transducers of the transforming growth factor β
(TGFβ) signaling pathway, are found to play an important regulatory role in the processing of miRNA. In the present review, we mainly
summarized the regulatory effects of the TGFβ/Smad signaling pathway on miRNA biogenesis. |
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