| 尹积荣杨凯△ 白玉兴王邦康.牙齿发育相关基因Osr2 的生物信息学分析[J].现代生物医学进展英文版,2011,11(14):2720-2723. |
| 牙齿发育相关基因Osr2 的生物信息学分析 |
| Bioinformation analysis for tooth development-related genes Osr2 |
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| DOI： |
| 中文关键词: 牙齿发育 生物信息学 同源比对 进化分析 Osr2 |
| 英文关键词: Tooth development Bioinformatics Homology alignment Phylogenetic analysis Osr2 |
| 基金项目:国家自然科学基金资助项目（30600718）；北京市自然科学基金（7072028） |
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| 中文摘要: |
| 目的：为生物学实验研究Osr2 与牙齿发育的关系提供思路和参考。方法：本文运用生物信息学的同源比对、进化分析等方
法，对Osr2 及其编码蛋白的生物信息学特征进行分析。结果：结果显示Osr2 蛋白质无信号肽,是非跨膜的疏水性蛋白,具有C2H2
型、CHY 型锌指结构域，是一类进化保守，高度同源的转录因子。结论：这一结果可为Osr2 深入的结构与功能分析及利用提供进
一步的信息与参考。 |
| 英文摘要: |
| Objective: The purpose of this research is to provide the idea and reference for biology experiment on the relationship
between Osr2 and tooth development. Methods: Analysis the bioinformatics characteristics of Osr2 by softwares provided by Internet and
homology alignment and phylogenetic analysis. Results: Results show that Osr2 located outside cytomembrane ,has no signal peptide,
hydrophobic protein with C2H2 type Zinc finger domain and CHY-type Zinc finger domain. Osr2 is the transcription factor with high
conserved domain and evolution gradually. Conclusion: It will be very valuable for the deep study of the structure and function of Osr2
further. |
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