| 王小燕1 林若飞1 史道华1,2△ 白志峰1 杨朋范3.多药耐药基因1 C3435T 多态性与癫痫耐药的关联性研究[J].现代生物医学进展英文版,2011,11(14):2717-2719. |
| 多药耐药基因1 C3435T 多态性与癫痫耐药的关联性研究 |
| Association of C3435T Polymorphism in Multidrug Resistance Gene 1with Refractory Epilepsy |
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| DOI： |
| 中文关键词: P- 糖蛋白 癫痫 基因多态性 |
| 英文关键词: P-glycoprotein Epilepsy Polymorphism |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨我国癫痫患者P- 糖蛋白基因多态性（C3435T）与抗癫痫药物反应性的关联性。方法：采用PCR--RFLP (聚合酶链
反应-- 限制性片段长度多态性分析)的方法对156 例癫痫患者外周血进行分型。其中，耐药组癫痫患者85 例，有效组癫痫患者71
例。结果：耐药组癫痫患者CC 基因型21 例，占24.70%；有效组癫痫患者CC 基因型19 例，占26.76%。两组比较无显著差异性。结
论：本研究未发现P-gp C3435T 基因型与癫痫耐药的关联性。 |
| 英文摘要: |
| Objective: To discuss the association between the P-glycoprotein gene polymorphism and the efficacy of epilepsy drug.
Methods: Genotypes of the C3435T polymorphism were determined by the polymerase chain reaction restriction fragment length polymorphism
(PCR-RFLP) methods in 156 patients, Including refractory epilepsy group (85) and drug-responsive group(71). Results: In non
responders, 21 patients were CC genotype (24.70%). In responders, 19 patients were CC genotype (26.76%). Conclusion: There is no association
between the P-gp C3435T gene polymorphism and the response to antiepileptic drug treatment in Chinese patient with epilepsy. |
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