| 王丽岩1 王煜2 陈秀娟1 齐佳敏1 王海翔1.MUC16 对子宫内膜容受性的影响及其意义[J].现代生物医学进展英文版,2011,11(14):2696-2698. |
| MUC16 对子宫内膜容受性的影响及其意义 |
| Expression of MUC16 in Human Endometrium with Polycystic OvarySyndrome and Normal Endometrial Tissues |
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| DOI： |
| 中文关键词: 多囊卵巢综合征 子宫内膜容受性 粘蛋白 |
| 英文关键词: Polycystic ovary syndrome Endometrium receptivity MUC16 |
| 基金项目:内蒙古教育厅项目（NJZY08102） |
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| 中文摘要: |
| 目的：多囊卵巢综合征（Polycystic Ovary Syndrome，PCOS）系由于体内复杂的内分泌和代谢环境影响了子宫内膜稳态，导致
子宫内膜容受性下降，造成患者生育力减弱和不良妊娠结局。通过测定多囊卵巢综合征患者子宫内膜与正常生育力妇女增生期、
分泌早、中、晚期子宫内膜中MUC16 的相对表达量，本文探讨MUC16 与PCOS 患者子宫内膜容受性下降的关系，为临床上改善
PCOS 患者子宫内膜容受性，提高PCOS 患者的妊娠率，降低流产率提供一条新的可能途径。方法：选择PCOS 患者子宫内膜、正
常生育力妇女增生期、分泌早、中、晚期子宫内膜各20 例，用免疫组化SP 法检测MUC16 在各组的表达情况。结果：（1）MUC16 在
月经周期各期均有表达，在分泌中期表达最强。（2）PCOS 组MUC16 的表达较分泌中期组弱，差异有显著性（P<0.05）。结论：（1）在
子宫内膜中的表达呈周期性变化。（2）PCOS 患者子宫内膜中MUC16 表达异常可能使子宫内膜容受性下降，推测其与胚胎不能
正常着床或着床后发育不良、导致流产有关。 |
| 英文摘要: |
| Objective: To explore the expression and changes of MUC16 in human normal and polycystic ovary syndrome (PCOS)
endometrium during menstrual cycle. Methods: Immunohistochemistry was used to detect the level of MUC16 protein in normal endometrium
from 80 women and PCOS endometrium from 20 women. Results: MUC16 protein mainly expressed on the top surface of endometrium
epithelial cells and adenocytes in proliferative phase and secretory phase. The level of MUC16 protein in mid-secretory phase
were higher than those in proliferative phase,early and late secretory phase (P<0.05). MUC16 protein expression in PCOS group were
significantly lower than those in mid-secretory phase (P<0.05). Conclusion:MUC16 expressions in endometrium are changed in menstrual
cycle, which is probably play a role in the establishment of endometrium receptivity and embryo implantation. |
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