王丽岩1 王煜2 陈秀娟1 齐佳敏1 王海翔1.MUC16 对子宫内膜容受性的影响及其意义[J].现代生物医学进展英文版,2011,11(14):2696-2698. |
MUC16 对子宫内膜容受性的影响及其意义 |
Expression of MUC16 in Human Endometrium with Polycystic OvarySyndrome and Normal Endometrial Tissues |
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DOI: |
中文关键词: 多囊卵巢综合征 子宫内膜容受性 粘蛋白 |
英文关键词: Polycystic ovary syndrome Endometrium receptivity MUC16 |
基金项目:内蒙古教育厅项目(NJZY08102) |
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中文摘要: |
目的:多囊卵巢综合征(Polycystic Ovary Syndrome,PCOS)系由于体内复杂的内分泌和代谢环境影响了子宫内膜稳态,导致
子宫内膜容受性下降,造成患者生育力减弱和不良妊娠结局。通过测定多囊卵巢综合征患者子宫内膜与正常生育力妇女增生期、
分泌早、中、晚期子宫内膜中MUC16 的相对表达量,本文探讨MUC16 与PCOS 患者子宫内膜容受性下降的关系,为临床上改善
PCOS 患者子宫内膜容受性,提高PCOS 患者的妊娠率,降低流产率提供一条新的可能途径。方法:选择PCOS 患者子宫内膜、正
常生育力妇女增生期、分泌早、中、晚期子宫内膜各20 例,用免疫组化SP 法检测MUC16 在各组的表达情况。结果:(1)MUC16 在
月经周期各期均有表达,在分泌中期表达最强。(2)PCOS 组MUC16 的表达较分泌中期组弱,差异有显著性(P<0.05)。结论:(1)在
子宫内膜中的表达呈周期性变化。(2)PCOS 患者子宫内膜中MUC16 表达异常可能使子宫内膜容受性下降,推测其与胚胎不能
正常着床或着床后发育不良、导致流产有关。 |
英文摘要: |
Objective: To explore the expression and changes of MUC16 in human normal and polycystic ovary syndrome (PCOS)
endometrium during menstrual cycle. Methods: Immunohistochemistry was used to detect the level of MUC16 protein in normal endometrium
from 80 women and PCOS endometrium from 20 women. Results: MUC16 protein mainly expressed on the top surface of endometrium
epithelial cells and adenocytes in proliferative phase and secretory phase. The level of MUC16 protein in mid-secretory phase
were higher than those in proliferative phase,early and late secretory phase (P<0.05). MUC16 protein expression in PCOS group were
significantly lower than those in mid-secretory phase (P<0.05). Conclusion:MUC16 expressions in endometrium are changed in menstrual
cycle, which is probably play a role in the establishment of endometrium receptivity and embryo implantation. |
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