| 刘晓萃何守志.血管microRNAs 的研究进展[J].现代生物医学进展英文版,2011,11(13):2597-2600. |
| 血管microRNAs 的研究进展 |
| Progress on Research of AngiomiRs |
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| DOI： |
| 中文关键词: 血管microRNA 血管再生 治疗 |
| 英文关键词: AngiomiRs Angiogenesis Treatment |
| 基金项目: |
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| 中文摘要: |
| 血管再生在血管发展和内环境的稳定中起重要作用。错乱的血管再生导致多种疾病，如肿瘤和缺血性疾病。近年来研究证
实，MicroRNAs 在血管再生及调控内皮细胞功能中起重要作用，如miR-126 在内皮细胞中特异性表达并调控血管生成；miR-210
在缺氧导致的血管生成及内皮细胞存活中发挥重要作用；miR-17~92 簇在体外可以抑制内皮细胞的增殖及在基质胶中抑制血管
管腔的形成；miR-378、miR-296、miR-21 和miR-31 可促进肿瘤血管发生等。深入研究血管microRNAs 的体内功能，将为有效抑制
血管再生，改变血管病理发展提供一种新的治疗策略。 |
| 英文摘要: |
| Angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of
diseases, such as cancer and ischemia. Recent studies have revealed important roles of microRNAs in angiogenesis and endothelial cell
(EC) function. For example, miRNA-126 shows EC-specific expression and regulates angiogenesis; miR-210 is a crucial regulator of
angiogenesis and EC survival in response to hypoxia; inhibition of miR-17~92 in vitro represses EC sprouting and tube formation in
matrigel; miR-378, miR-296, miR-21 and miR-31 contribute to tumor angiogenesis and so on. The further study of angiomiRs function in
vivo will support a new therapeutic approach in the active suppression of angiogenesis and the settings of pathological vascularization. |
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