| 温玉刚王权彭志海.上海交通大学附属第一人民医院普外科[J].现代生物医学进展英文版,2011,11(13):2590-2593. |
| 上海交通大学附属第一人民医院普外科 |
| Advancement of RASSF6 and Malignant Tumors |
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| DOI： |
| 中文关键词: RASSF6 恶性肿瘤 抑癌基因 |
| 英文关键词: RASSF6 Malignant tumor Tumor suppressor gene |
| 基金项目:上海市科委基础研究重点项目（09JC1412400），上海市科委医学引导项目（10411967300） |
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| 中文摘要: |
| RAS 相关结构域家族（Ras Association Domain Family, RASSFs）由10 个成员组成，参与不同的细胞内机制如凋亡、细胞周
期控制、微管稳定性等，一些家族成员表现出肿瘤抑制功能。目前发现RASSF6 在肺癌、宫颈癌等实体瘤中表达下调，可能与肿瘤
形成有关，并可作为肿瘤治疗的潜在靶点。本文就RASSF6 与肿瘤的研究进展进行综述。 |
| 英文摘要: |
| The RAS-association domain family（RASSFs）, as a new Ras effector, consistant of 10 members. Some of the family
members are thought to function as tumor suppressors for they have been shown to have a diverse range of functions including cell cycle
regulation and the regulation of microtubule stability in addition to roles in the control of apoptosis and proliferation. RASSF6 expression
was reduced in lung cancer, cervical cancer and might relate to tumorigenesis. Furthermore, it might be a potential target for tumor
therapy. Here we review the current research progress on RASSFs, especially on RASSF6. |
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