| 王玉强盛净.磷脂酰肌醇3- 激酶对心脏的调节[J].现代生物医学进展英文版,2011,11(13):2578-2580. |
| 磷脂酰肌醇3- 激酶对心脏的调节 |
| Regulation of Phosphoinositide 3-kinases on the Heart |
| |
| DOI： |
| 中文关键词: PI3K/Akt 信号通路 心肌肥大 心衰 |
| 英文关键词: PI3K/Akt Signaling pathway Myocardial hypertrophy Heart failure |
| 基金项目: |
|
| Hits: 794 |
| Download times: 1070 |
| 中文摘要: |
| 磷脂酰肌醇3- 激酶(phosphatidylinosito1 3-kinase，PI3K)是体内很多生理过程中起关键作用的信号分子，PI3K 介导的信号转
导通路调节细胞的增生、分化、凋亡等活动。以往研究较多的是PI3K 与肿瘤发生发展的关系，最近很多研究发现PI3K 介导的信
号转导通路对心脏具有重要的调节功能。本文就近年来关于PI3K 的结构和功能以及PI3K 对心脏的调节的研究作一综述。 |
| 英文摘要: |
| Phosphoinositide 3-kinases (PI3K)plays an important role in cell responses including cell proliferationl,differentiation
and apoptosis.In the past,many studies focused on the effects of PI3K on genesis and development of tumor, however ,in recent years,
many researches have revealed that PI3K signaling pathway has significant effects on cardiac regulation.In this review,the structure and
function of PI3K and its roles in cardiac regulation will be summarized. |
|
View Full Text
View/Add Comment Download reader |
| Close |
