| 马加贵褚海辰△ 孙俊枝.下行疼痛易化系统在吗啡耐受机制中的作用[J].现代生物医学进展英文版,2011,11(13):2572-2574. |
| 下行疼痛易化系统在吗啡耐受机制中的作用 |
| Effect of Descending Pain Facilitation System in Developmentof Morphine Tolerance |
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| DOI： |
| 中文关键词: 吗啡耐受 疼痛 下行易化系统 延脑头端腹内侧区 |
| 英文关键词: Morphine tolerance Pain Descending facilitation RVM |
| 基金项目: |
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| 中文摘要: |
| 吗啡是临床上常用的一种阿片类镇痛药物，广泛用于治疗各种类型疼痛，但是长期应用吗啡会造成吗啡耐受，从而限制了
吗啡的临床应用。吗啡耐受的机制十分复杂，近年来的研究表明下行疼痛易化系统参与了吗啡耐受，本文拟对近年来此方面的研
究进行综述。 |
| 英文摘要: |
| Morphine is a most important powerful opioid analgesic that has been widely used to alleviate various types of pain,
but chronic use of morphine is accompanied by the development of morphine tolerance, which is one of the major problems associated
with morphine treatment, thus limiting the clinical application of morphine. the mechanisms underlying this phenomenon are very complex
and remain largely unknown, recent studies have demonstrated the participation of descending pain facilitation system in the development
of morphine tolerance. In this paper,recent progress in this field is reviewed, in order to provide some new approaches for therapy of morphine
tolerance. |
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