| 廖永强彭可君夏洪娇刘剑荣孟芳.抗中性粒细胞胞浆抗体、抗核抗体联合检测对类风湿关节炎
的诊断价值[J].现代生物医学进展英文版,2011,11(13):2535-2537. |
| 抗中性粒细胞胞浆抗体、抗核抗体联合检测对类风湿关节炎
的诊断价值 |
| Diagnostic Value of ANCA Combining with ANA Tests in Patientswith Rheumatoid Diseases |
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| DOI： |
| 中文关键词: 抗核抗体 抗中性粒细胞胞浆抗体 联合检测 类风湿性关节炎 |
| 英文关键词: ANA ANCA United detection Rheumatoid arthritis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨抗中性粒细胞胞浆抗体(ANCA) 与抗核抗体（ANA）联合检测对类风湿关节炎的临床意义。方法：采用IIF 法对82
例RA 患者(RA 组)、74 例非RA 自身免疫疾病患者(非RA 组)和52 例健康体检者(正常对照组)的血清ANCA 和ANA 谱进行了
检测分析,并用ELISA 法进行抗丝氨酸蛋白酶3 ( PR3)、抗髓过氧化物酶(MPO)、ANA 谱的定量检测。结果：RA 组82 例患者中，
64 例ANCA 阳性，阳性率为78.08% ，其中核周型( PANCA)37 例，阳性率为45.1 % ，胞浆型(CANCA) 27 例，阳性率为32.9%；非
RA 组74 例患者中有7 例ANCA 阳性率分别为9.4%；正常对照组50 例中没有一例ANCA 阳性。利用Elisa 法对患者血清进行
检测，分别能够特异的检测到PR3、MPO、抗双链DNA 抗体（抗ds-DNA 抗体）、抗ss-A 等抗体、抗SS-A 抗体、抗PM-SCL 抗体的
存在。结论：联合ANCA、ANA 检测有助于提高类风湿关节炎的诊断。 |
| 英文摘要: |
| Objective: To study the clinical significance of antineutrophil cytoplasmic antibody (ANCA) combining with
antinuclear antibody (ANA) tests in patients with reheumatiod(RA) diseases. Methods: The spectrums of ANCA and ANA in RA group
(n=82),non-RA group (n=74) and healthy control group (n=52) were tested by Indirect-Immunen-Flurocence methods；Anti-serine
proteinase 3, anti-MPO and ANA spectrum were detected by ELISA. Results: In RA group，there were 64 patients with ANCA-positive，
the positive rate was 78.08%;in non-RA group, 7 patients with ANCA-positive, the positive rate , 9.4%; there were no ANCA-positive
patients in the healthy control group. Conclusion: The joint detection of ANA and ANCA is helpful for the diagnosis of rheumatoid
diseases. |
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