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目的：检测妊娠高血压患者外周血中促Th2 的分子IL-4、IL-2 与IL-10 的水平，探讨IL-2/IL-10 在妊高症中的临床意义。方法：选择40 例未妊娠妇女为对照组，30 例正常妊娠妇女为妊娠组，28 例妊娠高血压患者为妊娠高血压组，ELISA 检测血清中 IL-4、IL-2 和IL-10 的水平。结果：与对照组外周血中IL-4 水平(0.53±0.04 )pg/ml 相比：正常妊娠组IL-4 水平升高至(0.91±0.03) pg/ml(P＜0.05)，妊娠高血压组IL-4 水平(0.67±0.35) pg/ml 升高但明显低于正常妊娠组(P＜0.01)。与对照组外周血中IL-2 水平（0.41±0.05)pg/ml 相比：正常妊娠组IL-2 水平升高至(0.82±0.11 )pg/ml(P＜0.01)；妊娠高血压组IL-2 水平高达1.57±0.22 (pg/ml)明显高于其它两组(P＜0.01)。妊娠高血压组外周血中IL-10 水平明显低于正常妊娠组IL-10 水平(P＜0.01)；妊娠高血压组外周血中 IL-2/IL-10 比值明显高于于对照组及正常妊娠组的比值。结论：妊娠高血压患者外周血中细胞因子IL-2 和IL-10 分泌异常且诱导 Th2 细胞产生的IL-4 降低，打破Th1/Th2 平衡，致使Th1 型免疫反应增强，使早孕期滋养细胞受到免疫损伤以致侵入能力下降，导致妊娠期高血压疾病的发生。

英文摘要:

Objective: To detect the levels of IL-4 and IL-2 and IL-10 in the patients with pregnancy-induced hypertension, and discuss the detection of IL-2/IL-10. Methods: Taking 40 cases of non-pregnant women as control group, 30 normal pregnant women as pregnancy group, 28 cases of pregnancy induced hypertension as pregnancy-induced hypertension group patients, we used ELISA to detect the levels of IL-4, IL-2 and IL-10 in their serum. Results: The levels of IL-4 in peripheral blood of pregnancy group was (0.91± 0.03) pg / ml , significantly higher than the level of IL-4 (0.53 ± 0.04) pg / ml in control group (P＜0.05). The levels of IL-4 in peripheral blood of pregnancy-induced hypertension group was (0.67± 0.35) pg / ml, significantly lower than the IL-4 level in normal pregnancy group (P＜0.01). IL-2 levels of (0.82±0.11) pg / ml in normal pregnancy group was higher than those of (0.41±0.05) pg / ml in control group; IL-2 levels of pregnancy-induced hypertension group was 1.57 ± 0.22 (pg / ml), significantly higher than that in the control group and normal pregnancy group (P ＜0.01). IL-10 in peripheral blood during pregnancy was significantly higher. IL-10 levels of pregnancy-induced hypertension was significantly lower than that in normal pregnancy group (P＜0.01); the IL-2/IL-10 ratio in pregnancy-induced hypertension group was significantly higher than that in the control group and the normal pregnancy group. Conclusion: IL-2 and IL-10 secretion were abnormal in pregnancy-induced hypertension in patients, and the IL-4 level which could induced the produce of Th2 cells was decreased, then the Th1/Th2 balance was break, making the Th1-type immune response increased, but the invasive capacity decreased of the first trimester trophoblast cells which was injured by immune response, finally resulting in the occurrence of pregnancy induced hypertension.

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