李延辉1 夏明汗2 康举龄2 谢敏如1 马少康3.HSP70 和P53 蛋白在甲状腺乳头状癌中的表达
及其与临床病理特征的关系[J].现代生物医学进展英文版,2011,11(13):2504-2507. |
HSP70 和P53 蛋白在甲状腺乳头状癌中的表达
及其与临床病理特征的关系 |
Expression of HSP70 and p53 and Their Relationship with PathologicalCharacteristics in Papillary Thyroid Carcinoma |
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DOI: |
中文关键词: 甲状腺乳头状癌 免疫组织化学 热休克蛋白70 p53 蛋白 |
英文关键词: Papillary thyroid carcinoma Immunohistochemistry HSP70 p53 |
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中文摘要: |
目的:探讨热休克蛋白70(HSP70)和P53 蛋白在甲状腺乳头状癌组织中的表达及其与临床病理特征的关系。方法:应用免疫
组织化学Envision 法检测35 例甲状腺乳头状癌组织、15 例甲状腺良性病变组织及15 例正常甲状腺组织中HSP70 和P53 蛋白
的表达,分析HSP70 和P53 蛋白的表达与甲状腺乳头状癌临床病理学特征的关系。结果:甲状腺乳头状癌组织中HSP7O 和P53
阳性表达率明显高于甲状腺良性病变组织及正常甲状腺组织(P<0.01)。HSP7O 在甲状腺乳头状癌组织中的表达与是否有颈部淋
巴结转移、浸润深度以及AJCC 分期密切相关(P<0.01),而与年龄、性别、肿瘤的大小以及分化程度无关(P>0.05)。P53 在PTC 组
织中的表达与组织分化程度、是否有淋巴结转移、浸润深度以及AJCC 分期密切相关(P<0.01), 而与年龄、性别、肿瘤的大小无关
(P>0.05)。HSP70 和P53 蛋白在PTC 组织中的表达呈正相关性(r=0.679,P<0.01)。结论:HSP70 和p53 蛋白在PTC 中均呈高表
达,并有协同作用,两者可作为预测PTC 的生物学行为和预后的参考指标。 |
英文摘要: |
Objective: To investigate the relationship of the expression of HSP70 and p53 with the pathological characteristic in
papillary thyroid carcinoma. Methods: The expression of HSP70 and p53 protein were detected with immunohistochemical EnVision plus
non-hiotin technique in 35 cases of papillary thyroid carcinoma,15 cases of benign thyroid diseases and 15 cases of normal tissues of
thyroid.Results: The positive expression rates of HSP70 and p53 protein in papillary thyroid carcinoma were significantly higher than
that in benign thyroid diseases and normal tissues of thyroid (P<0.01). The expression of HSP70 was positively related to lymph node
metascasis, AJCC clinical stage and the degree of infiltration (P<0.01). The expression of p53 was positively related to AJCC clinica1
stage, differentiation degree, lymph node metascasis and the degree of infiltration (P<0.01). The expression of HSP70 was positiye1y
correlated with p53 (r=0.679,P<0.01). Conclusion: The expression of HSP70 and p53 protein in papillary thyroid carcinoma were high.
There was the synergistic effect between HSP70 and p53. HSP70 and p53 protein may act as markers predicting biological behavior and
prognosis of papillary thyroid carcinoma. |
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