| 贾娜尔1 李奇凤1 张斌1 姚彤2 韩艳3.131 例住院肺炎患儿细菌感染现况及耐药谱分析[J].现代生物医学进展英文版,2011,11(13):2499-2501. |
| 131 例住院肺炎患儿细菌感染现况及耐药谱分析 |
| Current Status of Bacteria Infection in 131 Hospitalized Children withPneumonia and Analysis of Relative Antibiotic Resistance Spectrum |
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| DOI： |
| 中文关键词: 细菌性肺炎 病原菌 耐药 |
| 英文关键词: Bacterial pneumonia Pathogen Resistance |
| 基金项目: |
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| 中文摘要: |
| 目的：分析住院肺炎患儿的病原菌分布及其耐药性。方法：选择2009 年6 月至2010 年5 月，新疆维吾尔自治区人民医院儿
科住院的791 例肺炎患儿，采取下呼吸道痰液标本，进行细菌培养及药敏试验。结果：16.56%（131/791）患儿被确诊为细菌性肺炎
并且有明确的病原，其中，革兰阴性菌感染为75.57%（99/131），且以肺炎克雷伯氏菌、大肠埃希菌、阴沟肠杆菌多见；革兰阳性菌
感染为21.37%（28/131），以肺炎链球菌多见；真菌感染为6.87%（9/131），均为白色假丝酵母；9.92%（13/131）的患儿存在两种及以
两种上病原菌感染。鲍曼不动杆菌和肠杆菌对头孢类抗生素耐药严重，部分肺炎克雷伯菌、大肠埃希菌产β- 内酰胺酶（BLA），葡
萄球菌属耐青霉素G，肠球菌对氯洁霉素、红霉素和复方新诺明耐药率100%，而肺炎链球菌对红霉素耐药率100%。真菌对常用
抗菌药的耐药率为0。结论：我院住院肺炎患儿细菌性为16.56%。病原菌构成以革兰阴性菌为主，并且大多数病原菌耐药。临床
应根据痰液细菌培养和药敏结果，合理选择抗菌药物，以减少细菌耐药性，防止滥用抗生素。 |
| 英文摘要: |
| Objective: To investigate the distribution and resistance of pathogens in hospitalized children with pneumonia. Methods：
From June 2009 to May 2010, 791 hospitalized children with pneumonia were taken sputum specimens of lower respiratory tract for
bacterial culture and sensitivity test. Results：16.56% (131/791) of them were with definite pathogens.The infection rate of Gram-negative
bacteria was 75.57% (99/131), Klebsiella pneumonia, Escherichia coli, Enterobacter cloacae were more common. The infection rate of
Gram-positive bacteria was 21.37%(28/131), Streptococcus pneumonia was more common. And the infection rate of fungi was 6.87%
(9/131),all of them were white Candida. The rate of patients infected with two or more pathogens was 9.92%(13/131). Acinetobacter
baumannii and Enterobacte should be showed serious against Cephalosporins in antimicrobial sensitivity and resistance tests. Part of
Klebsiella pneumonia and Escherichia coli were ESBL, All of Staphylococcus was penicillin G-resistant, the drug resistant rates of
clindamycin, erythromycin and cotrimoxazole to Enterococcus was 100%, of erythromycin to Streptococcus pneumonia was 100%. As
for fungi, the drug resistant rate was 0. Conclusion：The infection rate of bacterial pneumonia in hospitalized children was 16.56%. The
main pathogen of bacterial pneumonia was gram-negative bacteria, and most of them were drug-resistant. According to results of
susceptibility tests, reasonable treatment could reduce the bacterial resistance. |
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