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目的：观察不同给药时间分别给予比索洛尔对非杓型原发性高血压患者的降压疗效和血压节律恢复的影响。方法：选取60 例非杓型高血压患者，采取随机平行对照试验，观察比索洛尔（n=30）每日早晨（8：00）给药2.5-10mg、比索洛尔（n=30）每日夜间（20：00）给药2.5-10mg 治疗8 周后的降压疗效。结果：两种给药方法均能降低非杓型高血压患者的全天血压（P＜0.05）。两种给药方法在白天的血压控制上无显著性差异（P＞0.05），但在夜间血压的控制上夜间服药降压效果具有显著性差异（P＜0.05）。夜间服药在血压节律恢复方面优于早晨服药（P＜0.05）,早晨服药组有10 例恢复杓型，夜间服药组有19 例恢复杓型。结论：比索洛尔的两种给药方式均能安全有效的降压，但对于非杓型高血压患者夜间服药优于早晨服药,更有利于血压节律的恢复。

英文摘要:

Objective: To investigate the effect of bisoprolol with different time on blood pressure control and circadian variability of dipper blood pressure for patients with Non-dipper hypertension. Methods: The patients were randomly divided into two parallel groups. All patients were treated with bisoprolol. The first group took bisoprolol at eight o'clock once-daily between 2.5mg and 10mg. The second group took bisoprolol at twenty o'clock once-daily between 2.5mg and 10mg. The efficiency of the 8 weeks' treatment and the change of the 24 hours blood pressure were detected. Results: The blood pressures of the patients in both groups decreased（P<0.05）. And there was no significant difference between the two groups for the day BP decrease (P>0.05), but taking bisoprolol at first group had a better efficacy than that in the second group of the ninght BP. On the recovery diurnal rhythm of blood pressure the first group was better than that of second group (P<0.05). There were 10 hypertensive patients with non-dipper pattern of blood pressure changed into dipper pattern in the first group while there were 19 patients changed in the second group. Conclusion: Two menthds of treatment can control the blood pressure safe and efficacy, but taking drug at eight o'clock was better for the Non-dippers Hypertension and the the diurnal rhythm of blood pressure than taking at twenty o'clock.

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