杨松1 何银1 薛丽萍1 羊柳2 季宇霞3.靖江地区宫颈病变患者高危型人乳头瘤病毒感染及其基因型分析[J].现代生物医学进展英文版,2011,11(12):2342-2344. |
靖江地区宫颈病变患者高危型人乳头瘤病毒感染及其基因型分析 |
Infection Rate Human Papilloma Virus and Genotype Distributionof Patients with Cervical Lesions in Jingjiang Area |
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DOI: |
中文关键词: 人乳头瘤病毒 高危型 宫颈癌 实时荧光PCR |
英文关键词: Human papilloma virus High-risk HPV types Cervical cancer Real-Time PCR |
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中文摘要: |
目的:研究靖江地区各组宫颈病变中高危型人乳头瘤病毒(HPV)感染率及其基因型分布。方法:采用实时荧光PCR 检测方
法检测334 例宫颈脱落细胞标本中高危型HPV 及其基因型。结果:高危型HPV 在宫颈炎组、湿疣组、低度鳞状上皮细胞内病变
(LSIL)组、高度鳞状上皮细胞内病变(HSIL)组中的感染率分别为24.2%、58.2%、49.3%、69.5%;HPV 16、18、33、58 型在宫颈病变
中是最常见的HPV 型别,其中,HPV16 型在宫颈炎组、湿疣组、LSIL 组、HSIL 组中所占比例逐渐增高,分别为17.9%、18.9%、
30.8%、41.9%。结论:高危型HPV 感染率随着宫颈病变程度的加重而升高,HPV16 型是高危型HPV 感染中的主要亚型,HPV18、
33、52、58 也较常见,其余型别很少。 |
英文摘要: |
Objective: To study the infection rate of human papilloma virus and genotype distribution of patients with cervical
lesions in Jingjiang area. Methods: Detect the high-risk HPV types and genotype in 334 cervical specimens of routine Pap with
Real-Time PCR. Results: The infection rate of high-risk HPV types in cervicitis group, condyloma group, LSIL group,HSIL group was
24.2%,58.2%,49.3%,69.5%, respectively. The most common genotype in cervical lesions is HPV 16,18,33,58;in which, the infection rate
of HPV16 in cervicitis group,condyloma group,LSIL group,HSIL group was 17.9%,18.9%,30.8%,41.9%, respectively. Conclusion: The
infection rate of high-risk HPV increases with the severity of cervical lesions. HPV16 is the main genotype of the high-risk HPV
infection. The other HPV types are more common. |
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