| 王晓露1 解方为2 陈曦2 张霞2 欧阳学农2.丹参酮IIA 对大鼠移植性肝癌的抑制作用[J].现代生物医学进展英文版,2011,11(11):2062-2064. |
| 丹参酮IIA 对大鼠移植性肝癌的抑制作用 |
| The Inhibitive Effect of Tanshinone IIA on Implanted Hepatoma in Rats |
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| DOI： |
| 中文关键词: 丹参酮IIA HMGB1 VEGF |
| 英文关键词: Tanshinone IIA HMGB1 VEGF |
| 基金项目:" 十一五" 军队中医药研发推广专项课题基金资助（2006051002） |
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| 中文摘要: |
| 目的：观察丹参酮IIA 对大鼠移植性肝癌的抑制作用。方法：将SD 大鼠随机分为假手术组、模型组、丹参酮IIA 高、低剂量
组。各组动物于移植术后12d 处死。分离肿瘤测量其体积，realtime RT-PCR 法和western blot 法检测肿瘤组织中HMGB1、VEGF
mRNA 和蛋白的表达。结果：丹参酮IIA 能明显降低肿瘤体积，降低肿瘤组织中HMGB1、VEGF mRNA 和蛋白的表达。结论：丹参
酮IIA 能抑制大鼠移植性肝癌的生长，其机制可能与抑制HMGB1、VEGF 表达有关。 |
| 英文摘要: |
| Objective: To study the effect of Tanshinone IIA on implanted hepatoma in rats. Method: Sprague Dawley rats were
divide into normal group, sham operated group and two Tanshinone IIA groups. Contents of HMGB1, VEGF protein and mRNA were
detected by immunohistochemical and real-time PCR methods, respectivly. Result: In Tanshinone IIA groups, Contents of HMGB1,
VEGF protein and mRNA were decreased markedly. Conclusion: Tanshinone IIA could inhibit the implanted hepatoma in rats. This
maybe be concerned with that it could inhibit the expression of HMGB1 and VEGF in the implanted hepatoma in rats. |
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