| 荆艳宋晓峰.蛋白质表面氨基酸特性研究进展[J].现代生物医学进展英文版,2011,11(10):1991-1994. |
| 蛋白质表面氨基酸特性研究进展 |
| Progress in Properties of Amino Acids on Surface of Protein Molecules |
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| DOI： |
| 中文关键词: 蛋白质表面特性 蛋白质相互作用界面 预测方法 |
| 英文关键词: The properties of protein surface Protein-protein interface Prediction methods |
| 基金项目:江苏省自然科学基金资助（BK2010500） |
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| 中文摘要: |
| 分布在蛋白质分子表面的暴露于溶剂的氨基酸所具有的一些特性对蛋白质的折叠和聚合过程、蛋白质- 蛋白质相互作用以
及蛋白质的功能具有重要影响。本文分析了蛋白质表面氨基酸在疏水性、保守性、静电势及结构方面的一些特性，阐述了近年来
国际上利用这些特性对蛋白质- 蛋白质相互作用界面进行预测的方法，最后介绍了几款预测蛋白质表面氨基酸的软件。 |
| 英文摘要: |
| The properties of the surface amino acids that exposed to the solvent can influence the fold and polymerization
processes, protein-protein interaction and the function of proteins. This paper analyzes the properties of surface amino acids such as
hydrophobicity, conservation, electrostatic potential and structural properties. Also, the methods using these properties to predict the
interfaces between two interacting proteins in the international filed were reviewed. Finally we introduced several softwares of predicting
surface amino acids. |
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