| 李雪1 张巍巍1 耿长新2 解祥军1 司君利1 王青1.Wnt 信号通路GS 蛋白在胃癌中的表达和临床意义[J].现代生物医学进展英文版,2011,11(10):1913-1916. |
| Wnt 信号通路GS 蛋白在胃癌中的表达和临床意义 |
| Expression of Target GS Protein in WNT Signaling Pathway in GastricCancer and Its Clinical Signlficance |
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| DOI： |
| 中文关键词: Wnt 信号通路 胃癌 谷氨酰胺合成酶(GS) 幽门螺杆菌 |
| 英文关键词: Wnt signaling pathway Gastric cancer Glutamine synthetase(GS) Helicobacter pylori (HP) |
| 基金项目: |
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| 中文摘要: |
| 目的：研究Wnt 信号通路的中GS 蛋白（谷氨酰胺合成酶）在胃癌组织中的表达，探索其在胃癌发生、发展中的意义。方法：
用免疫组织化学法测定胃癌组织（110 例）、肠化生组织（30 例）、不典型增生组织（20 例）及慢性浅表性胃炎组织（60 例）中GS 蛋
白表达。用快速尿素酶法与病理组织切片染色法检测上述各组织中HP 感染的情况，并予统计学分析比较其差异。结果：胃癌组
织GS 高蛋白表达与组织分型、分化程度、淋巴结转移密切相关(P <0.05), 与肿瘤大小、部位、TNM 分期、Borrmann 分型、性别、年
龄等无明显相关(P >0.05)。GS 表达与HP 感染密切相关。结论：GS 蛋白高表达同胃癌生物学行为密切相关，在胃癌的发生、发展
中起重要作用。 |
| 英文摘要: |
| Objective: To investigate the new target of Wnt signaling pathway Glutamine synthetase(GS) protein expression in the
Gastric cancer tissues and to explore its significance in the development of gastric cancer. Methods: Immunohistochemistry（SP method）
was used to detect GS expression in paraffin-embedded gastric cancer tissues of 110 cases, intestinal metaplasia tissues of 30 cases,
dysplasia tissues of 20 cases, chronic superficial gastritis tissues of 30 cases. Rapid urease and histopathologic staining method were
applied to test infectious status of Helicobacter pylori (HP), then en statistical analysis was performed . Results: GS protein expression is
closely related to histological type, differential grade, lymph node metastasis (P<0.05), while has no significant correlation with tumor
size, tumor location, TNM stage, Borrmann classification, gender, age of patients (P>0.05). It is worth noting that GS expression is
closely related to HP infection. Conclusion: GS overexpression is closely related to the biological behavior of gastric cancer and plays an
important role in the development of gastric carcinoma. |
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