| 胡军曾慰胡名松.格列吡嗪合并辛伐他汀对颈动脉粥样硬化斑块的疗效观察[J].现代生物医学进展英文版,2011,11(10):1907-1909. |
| 格列吡嗪合并辛伐他汀对颈动脉粥样硬化斑块的疗效观察 |
| Therapeutic Efficacy of Simvastatin plus Glipizide in Patients withCarotid Atherosclerotic Plaques |
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| DOI： |
| 中文关键词: 格列吡嗪 辛伐他汀 血脂 炎症因子 内膜- 中膜厚度 动脉粥样硬化 |
| 英文关键词: Glipizide Simvastatin Blood lipids Inflammatory factors Intima-media thickness（IMT） Atherosclerosis |
| 基金项目: |
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| 中文摘要: |
| 目的：研究辛伐他汀对治疗并发高脂血症的颈动脉粥样硬化斑块的影响,以及合用格列吡嗪对辛伐他汀的增效作用。方法：
将高脂血症并发颈动脉粥样硬化患者108 例，随机分为2 组，辛伐他汀治疗组和格列吡嗪合并辛伐他汀治疗组，6 个月治疗后，测
量血脂生化指标、炎症因子活性和高频率彩色多普勒超声内- 中膜厚度(IMT)。结果：两个治疗组，治疗后与治疗前相比，血脂指
标，炎症因子指标及其IMT 值都具有显著性差异（P<0.05）。与辛伐他汀单独治疗相比，格列吡嗪合并辛伐他汀治疗组的TC、TG
和HDL-C 没有显著性差异(P>0.05)，但LDL-C 显著减少(P<0.05)，两组间ET-1 和TNF-α 以及IMT 值差异显著（P<0.05）。结论：
辛伐他汀能够改善血脂水平，降低炎症因子活性，进而对颈动脉粥硬化具有治疗作用，而合并格列吡嗪治疗能够起到增效作用。 |
| 英文摘要: |
| Objective: To evaluate the therapeutic efficacy of simvastatin in patients with carotid atherosclerotic plaques
complicated with hyperlipidemia，and the synergistic effect of glipizide. Methods: All the 108 patients were divided into two groups：
group treatment with simvastatin and group treatment with simvastatin and glipizide. After treatment for 6 months, we measured the
biochemical indicator of blood fat, included TC，TG，LDL-C and HDL-C ，the activity of inflammatory factors, included ET-1 and
TNF-α, and the intima-media thickness (IMT). Results: Both of the 2 groups, the scores of biochemical indicator of blood lipids, activity
of inflammatory factors and intima-media thickness (IMT) were changed significantly after treatment (P<0.05). Compared with group
treatment with simvastatin, the changes of the scores of TC，TG and HDL-C were not significant (P>0.05). However, the scores of
LDL-C, activity of inflammatory factors and IMT were decreased significantly (P<0.05). Conclusion: Simvastatin could improve carotid
atherosclerosis, through improving the level of blood lipids and reducing the activity of inflammatory factors, and glipizide had a
synergistic effect. |
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