| 李曼冯德云.丙型肝炎病毒感染与肝细胞癌相关关系的研究进展[J].现代生物医学进展英文版,2011,11(9):1797-1800. |
| 丙型肝炎病毒感染与肝细胞癌相关关系的研究进展 |
| Relationship Between HCV Infection and Hepatocarcinoma |
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| DOI： |
| 中文关键词: 丙型肝炎病毒 肝细胞肝癌 发生机制 |
| 英文关键词: HCV Hepatocellular carcinoma Mechanism |
| 基金项目:国家自然科学基金资助（30901452） |
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| 中文摘要: |
| 世界上有数亿的人口患有丙型肝炎，而丙型肝炎病毒（HCV）的感染易转为慢性，引起肝细胞炎性坏死及再生，导致肝纤维
化、硬化甚至肝细胞癌（HCC），是危害人类健康的一个重要卫生问题。HCV 的感染可导致HCC 的发生，但HCV 相关性HCC 的
发生机制尚不清楚。免疫逃避机制是感染慢性化的一个重要原因，病毒通过其基因组编码的蛋白使肝细胞发生转化，可能是肝细
胞癌变的重要机制。 |
| 英文摘要: |
| There is hundreds of millions of population in the world suffering from hepatitis C,and this is an important health
problem to human. Hepatitis C virus(HCV) infection prone to chronic inflammation, and cause injury, necrosis and regeneration, leading
to liver fibrosis and even hepatocellular carcinoma (HCC).HCVinfection can lead to the occurrence ofHCC, butHCV-related pathogenesis of
HCC has been in the study. Immune escape mechanism is an important reason for chronic infection, and the virus proteins may be the important
mechanism for malignant transformation.
Key words: HCV; Hepatocellular carcinoma; |
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