| 薛晓静白玉赟吴开春△ 樊代明.胃癌治疗候选新药GX1-rmhTNFα一般药理学研究[J].现代生物医学进展英文版,2011,11(9):1775-1778. |
| 胃癌治疗候选新药GX1-rmhTNFα一般药理学研究 |
| General Pharmacology of GX1-rmhTNFα: A Drug Candidatefor Gastric Cancer |
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| DOI： |
| 中文关键词: GX1-rmhTNFα 一般药理学 |
| 英文关键词: GX1-rmhTNFα General pharmacology |
| 基金项目:创新药物研究开发（2009ZX09103）；国家863 计划（2006AA02Z103，2006AA02A402）；
军队重点项目（06G087）；国家自然科学基金重大项目（81090270,81090273） |
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| 中文摘要: |
| 目的：通过研究GX1-rmhTNFα 对动物重要生命功能的影响，观察其主要药效学以外的药理作用，为临床研究和安全用药
提供信息。方法：分别取大鼠、小鼠肌肉注射，测试GX1-rmhTNFα 对动物中枢神经系统、心血管系统、呼吸系统的影响。结果：
GX1-rmhTNFα三个剂量组对动物中枢神经系统，呼吸系统，心血管系统无明显影响，与生理盐水对照组比较P >0.05。结论：在本
实验中，GX1-rmhTNFα对小鼠的中枢神经系统无明显影响，对大鼠呼吸系统，心血管系统无显著性影响，提示其不良反应小。 |
| 英文摘要: |
| Objective: To determine the effect of GX1-rmhTNFαto the vital organs or systems the functions of are acutely critical
for life, identify undesirable phamacodynamic properties of them, to observe the general pharmacology of polysaccharides from
GX1-rmhTNFαexcept the main phamacodynamics, and then provided the experimental basis for human safety. Methods: Mice given
GX1-rmhTNFαfor injection respectively by tail iv were determined the influence on cardiovascular, respiratory and central nervous system
of animals. Results: The spontaneous activity and coordinated movement and pentobarbital sodium-induced hypnosis in mice were
not obviously affected by the 3 doses of GX1-rmhTNFαinjection. The blood pressure and heart rate and respiratory system in mice had
no obvious difference by the 3 doses of GX1-rmhTNFαinjection (P>0.05). Conclusion: The drug had no effects on nervous, cardiovascular
and respiratory systems of the animals. It exerted that the systematic side of GX1-rmhTNFαis little. |
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