| 赵荣磊徐林浩△ 沈毅江玉华李发恩.β-catenin、cyclinD1 在胸腺肿瘤中的表达及意义[J].现代生物医学进展英文版,2011,11(9):1737-1740. |
| β-catenin、cyclinD1 在胸腺肿瘤中的表达及意义 |
| Expression and Significance ofβ-catenin and CyclinD1 in Thymic Tumor |
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| DOI： |
| 中文关键词: β-catenin cyclinD1 胸腺肿瘤免疫组化 |
| 英文关键词: β-catenin cyclinD1 thymic tumor immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：研究β-catenin、cyclinD1 在胸腺肿瘤的表达及其意义。方法：采用免疫组化pv6000 法检测69 例胸腺肿瘤中
β-catenin 及cyclinD1 的表达。结果：β-catenin 与cyclinD1 在胸腺肿瘤中的阳性表达率均为（53.62%） 明显高于正常胸腺组织
（0%）（P=0.027）。β-catenin 的阳性表达的差异在A、AB、B1、B2、B3 及C 型胸腺肿瘤各型之间存在统计学意义（X2=24.676，P<0.
01）。其表达的在A、AB 及B1 型与B2、B3 及C 型（无/ 低度危险组肿瘤与中/ 高度危险组肿瘤）之间表达的差异存在统计学意义
（X2=21.955，P<0.01）。CyclinD1 在A、AB、B1、B2、B3 及C 型胸腺肿瘤中的阳性表达的差异存在统计学意义（X2=14.393，P=0.
013）。其表达在A、AB 及B1 型与B2、B3 及C 型（无/ 低度危险组肿瘤与中/ 高度危险组肿瘤）之间表达的差异存在统计学意义
（X2=10.470，P=0.001）。在胸腺肿瘤中，β-catenin 的表达与cyclinD1 表达呈正相关关系（r=0.449，P<0.01）。结论：β-catenin、
cyclinD1 对于判定胸腺肿瘤的恶性程度可能有重要的参考价值。Wnt/β-catenin 信号传导通路在胸腺肿瘤的发生过程中可能发挥
重要作用。 |
| 英文摘要: |
| Objective: The objective of this experiment is to explore the expression and significance of β-catenin and cyclinD1 in
thymic tumor. Methods: Immunohistochemical pv6000 was used to detected the expression of β-catenin and cyclinD1 in 69 cases of
thymic tumor. Results: The positive expression ratio of β-catenin and cyclinD1in thymic tomor both were 53.26%，which were significantly
higher than of normal thymus(0%)(P=0.027). The positive expression ratio of β-catenin in thymic tomor were significantly different
among type A,AB,B1,B2,B3 and C of thymic tumor (X2=24.676,P<0.01). The positive expression ratio ofβ-catenin was significantly
higher in B2,B3 and C types than in A,AB,and B1 types (X2=21.955,P<0.01). The positive expression ratio of cyclinD1 in thymic tomor
were significantly different among type A,AB,B1,B2,B3 and C of thymic tumor (X2=14.393,P=0.013). The positive expression ratio of
cyclinD1 was significantly higher in B2,B3 and C types than in A,AB,and B1 types(X2=10.470,P<0.01). The expression ofβ-catenin can
be positively corelated with that of cyclinD1(r=0.449,P<0.01). Conclusion:β-catenin and cyclinD1 maybe have important reference value
for determining the malignancy of thymic tumors.Wnt/β-catenin signaling pathway may play important roles in the tumorigenesis of
thymic tumors. |
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