| 郭晓东熊璐李小溪刘树红李筱涵孙志强史晨辉赵景民.干扰素γ和白介素10 在慢性乙型重型肝炎中的变化[J].现代生物医学进展英文版,2011,11(9):1697-1699. |
| 干扰素γ和白介素10 在慢性乙型重型肝炎中的变化 |
| INF-γand IL-10 in patients with chronic serious hepatitis B |
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| DOI： |
| 中文关键词: 慢性乙型重型肝炎 干扰素γ 白介素10 |
| 英文关键词: chronic serious hepatitis B INF-γ IL-10 |
| 基金项目:国家传染病重大专项基金（2008ZX10002-005-6） |
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| 中文摘要: |
| 目的：探讨INF-γ和IL-10 在慢性乙型重型肝炎中的作用。方法：搜集不同患者血样，提取血清，使用ELISA 方法检测不同
患者不同时期的血清INF-γ 和IL-10 水平，并进行相关统计。结果：本研究发现，和其它肝炎对照组及健康对照组相比，慢性乙型
重型肝炎患者的血清INF-γ 水平显著升高，IL-10 水平显著降低。尽管在不同预后的患者中，INF-γ 水平差异并不明显，但是随
着治疗生效，INF-γ水平会出现明显的下降。结论：慢性乙型重型肝炎和其它慢性肝炎相比，INF-γ和IL-10 表达存在着差异，而
且INF-γ可能是一种比较有效的监控慢性重型肝炎病程以及疗效的指标。 |
| 英文摘要: |
| Objective: To investigate the role of INF-γ and IL-10 in chronic serious hepatitis B patients. Methods: Sera of different
groups of patients were collected and IL-10 and INF-γ serum levels were detected by ELISA. Result: Statistic analysis showed that
compared with normal control or other hepatitis B patients, the chronic serious hepatitis B patients showed significantly higher serum
INF-γ level and lower serum IL-10 level. The INF-γ level had no difference between the patient who was cured or not. But when patients
were cured, the INF-γ level was decreased significantly while IL-10 did not changed a lot. Conclusion: Compared with other type
of hepatitis B patients, INF-γ and IL-10 level balance in chronic serious hepatitis B patients was disturbed, and INF-γ may become a
potential molecular marker to monitor the disease process. |
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