| 吕伟1 张晓红1 高扬2△ 韩冰1.平阳霉素及其微球制剂的研究进展[J].现代生物医学进展英文版,2011,11(8):1589-1590. |
| 平阳霉素及其微球制剂的研究进展 |
| Research Advances in Pingyangmycin and Pingyangmycin Microspheres |
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| DOI： |
| 中文关键词: 平阳霉素 博莱霉素 微球 |
| 英文关键词: Pingyangmycin Bleomycin Microsphere |
| 基金项目: |
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| 中文摘要: |
| 平阳霉素自发现以来一直作为抗肿瘤的一线用药得到人们的广泛关注。近年来，将平阳霉素制备成微球剂型，改变其体内
代谢过程，延长药物的作用时间，增强平阳霉素的疗效成为医药学界的研究热点。本文首先通过平阳霉素与博来霉素的对比体现
出平阳霉素的优势；之后对平阳霉素的临床应用、不良反应等方面进行了相关介绍，经总结得出平阳霉素具备高效低毒的特点；
最后对平阳霉素微球研究的最新进展进行了概括，并提出了该药物在未来应用方面的展望。 |
| 英文摘要: |
| The first choice anti-tumor drugs pingyangmycin has been widely applied in hospital since it is discovered. Recent
years, preparing pingyangmycin microsphere formulation, changing its metabolic process in vivo, prolonging drug effect and enhancing
its effectiveness turn to be a hotspot in medicine. This article first compared pingyangmycin with bleomycin and reflected the advantage
of the former. Afterwards, we introduced the clinical applications and adverse reactions of this durg, we concluded that the drug is
efficient; in the end, we summarized the latest research progress of pingyangmycin microsphere and predicted the evolution on the
application aspects in the future. |
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