| 李开亮司全金△ 张帷.氯吡格雷联合阿司匹林治疗老年冠心病的临床疗效观察[J].现代生物医学进展英文版,2011,11(8):1529-1531. |
| 氯吡格雷联合阿司匹林治疗老年冠心病的临床疗效观察 |
| Clinical study of clopidogrel combined with aspirin for elderly patientswith coronary heart disease |
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| DOI： |
| 中文关键词: 氯吡格雷 阿司匹林 血小板聚集 老年冠心病 |
| 英文关键词: clopidogrel aspirin platelet aggregation coronary heart disease |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨氯吡格雷联合阿司匹林治疗老年冠心病（CHD）的临床疗效和安全性。方法：60 例老年CHD 患者随机分为治疗组
和对照组。对照组采用阿司匹林治疗，治疗组采用氯吡格雷联合阿司匹林治疗，治疗4 周后观察血小板聚集率（PAG）和凝血功能。
结果：治疗4 周后，治疗组PAG 显著下降，APTT 显著上升，与治疗前和对照组比较均有显著性差异（P<0.05）；两组治疗前后PT、
PA 变化差异无统计学意义（P>0.05）。两组均未出现不良反应。结论：阿斯匹林联合氯吡格雷治疗老年CHD 患者，较单用阿斯匹林
治疗更能有效地抑制血小板聚集和预防血栓形成，并能得到更好的临床疗效。 |
| 英文摘要: |
| Objective : To investigate the clinical efficacy and safety of clopidogrel combined with aspirin for treating the old
patients with coronary heart disease (CHD). Methods: A total of 60 elderly patients with CHD were divided randomly into the treatment
group and control group. The control group's patients were given aspirin therapy, the treatment group's patients were given the treatment
of clopidogrel combined with aspirin. The platelet aggregation rate (PAG) and coagulation were observed after treatment for 1 week.
Results: After treatment for 4week, the PAG of the treatment group was significantly decreased, the APTT significantly increased,
compared with the prior-treatment and control group the difference was significant (P < 0.05); The PT and PA of the two group were not
statistically significant between the prior-treatment and post-treatment (P> 0.05). The two groups were not adverse reactions. Conclusion:
Compared with aspirin therapy, the clopidogrel combined with aspirin for treating the old patients with CHD can effectively inhibit
platelet aggregation and prevent thrombosis. |
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