| 贾雷1 李扬2△ 孙梅2 崔伟2 宋振迪2.TNRC9 基因rs12443621A/G 多态性与中国女性乳腺癌易感性及临床病
理关系的研究[J].现代生物医学进展英文版,2011,11(8):1476-1478. |
| TNRC9 基因rs12443621A/G 多态性与中国女性乳腺癌易感性及临床病
理关系的研究 |
| Implication of the TNRC9 rs12443621A/G Polymorphisms in BreastCancer in Chinese Women |
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| DOI： |
| 中文关键词: 乳腺癌 易感性 单核苷酸多态性 TNRC9 基因 rs12443621 |
| 英文关键词: Breast cancer Liability Single Nucleotide Polymorphisms TNRC9 gene rs12443621 |
| 基金项目: |
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| 中文摘要: |
| 目的：研究TNRC9/LOC643714 基因rs12443621A/G 多态性与乳腺癌易感性及临床病理之间的关系。方法：DNA 试剂盒提
取321 例乳腺癌患者和340 例正常女性静脉血全基因组DNA，PCR 扩增目的基因片段，提取扩增样本进行DNA 测序检测分析
rs12443621 多态性。应用SPSS17.0 软件对实验结果进行统计学分析。结果：应用SPSS17.0 软件对TNRC9/LOC643714 基因
rs12443621A/G 多态性AA、AG、GG 进行卡方检验分析，结果显示三种基因型分布在病例组及对照组中无统计学意义(X2=1.43,
P＞0.05)，与乳腺癌易感性无关，与乳腺癌病理分型、ER、PR、HER-2 状态以及淋巴结是否转移无相关性(X2=2.90,P＞0.05; X2=2.25,
P＞0.05; X2=1.671,P＞0.05; X2=1.34,P＞0.05; X2=3.24, P＞0.05)。结论：TNRC9 基因rs12443621A/G 多态性与乳腺癌易感性及临床
病理特征无关，不能作为独立的基因标志物对乳腺癌进行早期检测和诊断。 |
| 英文摘要: |
| Objective: To investigate the relationship between the rs12443621 polymorphisms of TNRC9/ LOC643714 and breast
cancer risk and clinico-pathological characteristics in Chinese women. Methods: Genomic DNA was extracted from peripheral blood.
The Single Nucleotide Polymorphisms of the TNRC9/LOC643714 rs12443621, from breast cancer of 321 cases and 340 controls, were
detected by polymerase chain reaction (PCR) and direct DNA sequencing. Results: The genotypes of rs12443621 can not increase the risk
for breast cancer(X2=1.43,P＞0.05). There was no relationship between the genotypes and pathological category, lymph node metastases,
ER status or PR status or Her-2 status (X2=2.90,P＞0.05; X2=2.25,P＞0.05; X2=1.671,P＞0.05; X2=1.34,P＞0.05; X2=3.24, P＞0.05).
Conclusion: There was no relationship between three genotypes of rs12443621A/G and individual susceptibility or clinic pathological
characteristics of breast cancer. |
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