| 郭晓东孟繁平△ 熊璐.肝细胞肝癌E-Cadherin 蛋白的表达及其对判断肝癌肝移植
疗效的意义[J].现代生物医学进展英文版,2011,11(8):1469-1471. |
| 肝细胞肝癌E-Cadherin 蛋白的表达及其对判断肝癌肝移植
疗效的意义 |
| Relationship Between E-Cadherin Expression and Prognosis of LiverTransplant Patients with Hepatocellular Carcinoma |
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| DOI： |
| 中文关键词: 肝细胞肝癌 肝移植 预后 上皮钙黏蛋白 免疫组织化学 |
| 英文关键词: Hepatocellular carcinoma Liver transplantation Prognosis E-Cadherin Immunohistochemistry |
| 基金项目:国家自然科学基金青年基金项目（30901795） |
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| 中文摘要: |
| 目的：探讨E-Cadherin 蛋白在肝细胞肝癌组织中的表达及其对判断肝癌肝移植患者预后的价值。方法：选择肝细胞肝癌行全
肝移植患者68 例，应用免疫组化方法检测其切除的肝癌组织和癌旁正常肝组织中E-Cadherin 蛋白的表达情况，并对患者进行移
植术后随访，分析E-Cadherin 蛋白表达与肝癌肝移植患者预后的关系。结果：肝癌组织中E-Cadherin 蛋白阳性表达率明显低于癌
旁组织(P<0.01)。经Logrank 检验分析显示，E-Cadherin 蛋白低表达组移植后的无瘤生存率明显低于E-Cadherin 蛋白高表达组
(P<0.01)。多因素Cox 回归分析显示，E-Cadherin 蛋白表达是影响肝细胞肝癌患者肝移植术后肝癌复发的独立预后因素之一。结
论：E-Cadherin 蛋白表达是一个预测肝细胞肝癌患者肝移植预后的重要因子。 |
| 英文摘要: |
| Objective: To investigate the expression of E-Cadherin in patients with human hepatocellular carcinoma(HCC)，and
evaluate the prognosis of patients after liver transplantation．Methods: The expression of E-Cadherin protein was detected with
immunohistochemical analysis in 68 cases of HCC. With follow up, the prognostic value of E-Cadherin in HCC patients undergoing liver
transplantation were explored．Results: The positive expression rates of E-Cadherin protein in tumor tissues were significantly lower
than that in pericarcinoma tissues in HCC (P<0.01)．The relapse-free survival rate was significantly lower in E-Cadherin positive group
than that in E-Cadherin negative group．Multivariate analysis with the Cox proportional hazards model showed that E-Cadherin protein
was an independent prognostic factor for HCC patients after liver transplantation．Conclusions: The expression of E-Cadherin protein is
an independent prognostic factor for HCC patients undergoing liver transplantation． |
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