Article Summary
肖会敏何悦王四旺△ 王剑波谢艳华袁娟丽何中民.椒目仁油的成分分析及对家兔高血脂模型的影响[J].现代生物医学进展英文版,2011,11(8):1454-1457.
椒目仁油的成分分析及对家兔高血脂模型的影响
Component Analysis of Semen Oil of Zanthoxylum Bungeanum Maximand Its Effect on Hyperlipidemic Rabbits' Model
  
DOI:
中文关键词: 气- 质联用仪  椒目仁油  胆固醇  甘油三酯  高密度脂蛋白
英文关键词: GC-MS  Semen oil of the Zanthoxylum bungeanum Maxim  CH  TG  HDL
基金项目:陕西省“13115”科技创新项目(2008ZDKG- 61)
Author NameAffiliation
XIAO Hui-min, HE Yue, WANG Si-wang△, WANG Jian-bo, XIE Yan-hua, YUAN Juan-li, HE Zhong-min 第四军医大学药学系药物研究所 
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中文摘要:
      目的:分析椒目仁油的成分及探讨其对家兔高血脂模型的影响;方法:①采用GC-MS 分析椒目仁油的成分;②建立家兔高 血脂模型后,以CH、TG、HDL-C 及血液粘度为检测指标,比较椒目仁油的量效与时效关系;结果:①椒目仁油的主要成分是α- 亚麻酸酯与亚油酸等,总相对含量为71.34%;②每个椒目仁油组与模型组及对照组比较均能明显降低CH(P<0.01)、TG(P< 0.01)、血液粘度(P<0.01)以及明显升高HDL-C(P<0.01),其剂量效果是椒目仁油25mg/kg 组<50mg/kg 组<100mg/kg 组,其时 间效果是用药后第2 周<第4 周<第6 周;结论:椒目仁油调节血脂的作用主要依赖其中不饱和脂肪酸即α- 亚麻酸与亚油酸, 其调节血脂的效果随着椒目仁油剂量的增加而加强,同时随着使用时间的延长而加强。
英文摘要:
      Objective: To analyze the components of Zanthoxylum bungeanum Maxim and to investigate the effect on hyperlipidemic rabbits'model. Methods: ①Use GC-MS to analyze the components. ② Compare the amount-effect with the time-effect , TC,TG,HDL-C and blood viscosity as the detection indexes. Results:①The main components of Zanthoxylum bungeanum Maxim are α-octadecatrienoic acid and linoleic acid, the amount of which is 71.34%.② CH(P<0.01),TG(P<0.01), whole blood viscosity(P< 0.01)significantly decrease and HDL-C increase (P<0.01)in the model group and blank group compared that of Zanthoxylum bungeanum Maxim group.And the amount-effect is 25mg/kg group<50mg/kg group<100mg/kg group. And the time-effect is after 2 weeks<after 4 weeks<after 6 weeks after medication. Conclusion:①The regulating effect of Zanthoxylum bungeanum Maxim on lipidemia depended on α-octadecatrienoic acid and linoleic acid which was increased with the increasing dosage and time.
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