| 朱虹廖江涛李亲亲陈刚肖梅玉.四联疗法治疗幽门螺杆菌阳性胃溃疡的疗效观察[J].现代生物医学进展英文版,2011,11(7):1330-1335. |
| 四联疗法治疗幽门螺杆菌阳性胃溃疡的疗效观察 |
| Observation on curative effect of quadruple therapy in Helicobacterpylori-positive gastric ulcer |
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| DOI： |
| 中文关键词: 胃溃疡 埃索美拉唑 瑞巴派特 四联疗法 |
| 英文关键词: gastric ulcer esomeprazole rebamipide quadruple therapy |
| 基金项目: |
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| 中文摘要: |
| 目的：观察埃索美拉唑联合瑞巴派特、阿莫西林、克拉霉素治疗幽门螺杆菌阳性胃溃疡临床疗效。方法：60 例确诊的Hp 阳性
胃溃疡患者随机分为对照组（30 例）和治疗组（30 例），其中对照组患者给予奥美拉唑+ 阿莫西林+ 克拉霉素三联法治疗，实验组
给予埃索美拉唑+ 瑞巴派特+ 阿莫西林+ 克拉霉素四联法治疗。观察比较两组患者临床症状缓解情况，溃疡愈合率、Hp 根除率
及溃疡复发率。结果：①经过治疗，所有患者腹痛、腹胀、反酸、暧气等临床症状积分均显著降低（P<0.01），且治疗组下降程度大于
对照组，两组间差异有统计学意义（P<0.05）。②治疗组患者痊愈率为60.00%、总有效率为93.33%，明显高于对照组痊愈率
（43.33%）和总有效率（80.00%），两组间差异有统计学意义（P<0.05）。③治疗组S2 期获得率、溃疡愈合率和Hp 根除率分别为
93.33%、96.67%和93.33%，显著高于对照组60.00%的S2 期获得率、70.00%的愈合率和83.33%的根除率(P<0.01 或0.05)。④随访
1 年后，治疗组患者溃疡复发率为11.54%，与对照组32.00%的复发率比较差异有显著性（P<0.05）。结论：四联疗法治疗幽门螺杆
菌阳性胃溃疡可有效缓解患者临床症状，提高溃疡愈合质量，根除Hp 感染，减少复发，效果优于三联疗法。 |
| 英文摘要: |
| Objective: To observe the clinical effect of esomeprazole combined with rebamipide, amoxicillin and clarithromycin
on positive pylorus spirillum gastric ulcer. Methods: 60 patients with Helicobacter pylori-positive gastric ulcer were divided randomly into
control group (30 cases) and treatment group (30 cases). In the control group, patients were treated with omeprazole, amoxicillin and clarithromycin.
The treatment group was treated with esomeprazole, rebamipide, amoxicillin and clarithromycin. The change of symptoms,
clinical remission rate, ulcer healing rate, Hp eradication rate and ulcer recurrence rate were analyzed between the two groups. Results:
①After treatment, the clinical symptom score of abdominal pain, epigastric distention, sour regurgitation and belching significantly decreased
in all patients, especially in treatment group (P<0.01 or 0.05). ② The cure rate and total effective rate were 60.00% and 93.33%
respectively in treatment group, which were significantly higher than 43.33% and 80.00% in the control group (P<0.05). ③ The stage S2
achievement rate, ulcer healing rate and eradication rate of HP were 93.33%, 96.67% and 93.33% in treatment group, which were respectively
60.00%, 70.00% and 83.33% in control group, and there was significant difference between the two groups (P<0.01 or 0.05). ④ At
the end of 1 year follow-up, the ulcer recurrence rate were 11.54% and 32.00% in treatment and control group respectively, and there was
significant difference between the two groups (P<0.05). Conclusion: Quadruple therapy of Hp-positive gastric ulcer could relieve the clinical
symptom of patients, improve the quality of ulcer healing, eradicate Hp, and prevent reoccurrence, which is better than triple therapy. |
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