| 刘辉张斌△ 张顺△ 张庆王元元王文涛刘成科.影响肝切除术后行TACE 患者预后因素的分析[J].现代生物医学进展英文版,2011,11(7):1293-1297. |
| 影响肝切除术后行TACE 患者预后因素的分析 |
| Analysis of Prognostic Factors Affecting Patients Receiving TACE afterLiver Resection Surgery |
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| DOI： |
| 中文关键词: 原发性肝细胞肝癌 经肝动脉化疗栓塞(TACE) 预后 |
| 英文关键词: Liver neoplasms TACE Prognosis |
| 基金项目: |
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| 中文摘要: |
| 目的：对原发性肝细胞肝癌(HCC)肝部分切除术后行经肝动脉化疗栓塞(TACE)的病人和未行TACE 病人影响其预后的多
种因素进行分析和评价，为肝切除术后是否行TACE 治疗寻找筛选条件。方法：对我院2003~2008 年期间在我院肝胆外科行原发
性肝细胞肝癌手术治疗221 例（术后介入治疗103 例，术后非介入治疗118 例）患者进行全面随访了解患者的预后情况，分别对
术后接受介入治疗和非介入治疗两组通过Kaplan-Meier 及COX 回归分析影响预后的因素，包括：年龄、性别、血清HBsAg、肿瘤
直径、肿瘤大体分型、有无癌栓形成，肿瘤分期（TNM）共7 项指标。结果：在1 年生存期内介入治疗组中的性别、年龄、血清
HBsAg、肿瘤直径、肿瘤大体分型无统计学意义（p>0.05），有无癌栓形成及肿瘤分期有意义（p<0.05）；非介入组内年龄、性别、血清
HBsAg 无统计学意义，肿瘤直径、肿瘤大体分型、有无癌栓形成，肿瘤分期有意义；在3 年生存期内介入治疗组中的以上指标无统
计学意义，而非介入组在肿瘤直径、有癌栓形成及肿瘤分期方面与统计学意义。结论：对于肿瘤直径>5cm 及术后病理证实为低分
化的患者给予积极TACE 治疗可明显提高近期生存率。 |
| 英文摘要: |
| Objective: To find filtering conditions for conducting TACE treatment after liver resection surgery by analyzing and
evaluating various prognosis factors affecting patients receiving TACE and not receiving TACE after having partial hepatectomy of
primary hepatocellular carcinoma (HCC). Methods: To analyze the prognosis of 221 patients (103 received postoperative interventional
therapy and 118 received postoperative non-interventional treatment) receiving primary HCC surgery treatment in our hospital during the
period from 2003 to 2008. And analyze the factors affecting prognosis in the group receiving interventional therapy after surgery and the
group receiving non-interventional treatment after surgery via Kaplan-Meier and COX regression, which include age, gender, serum
HBsAg, tumor size, tumor gross type, with or without cancerembolus formation, and Tumor stage (TNM). Results: In one-year survival
period in the intervention group, age, sex, serum HBsAg, tumor size, and tumor gross type had no statistical significance (p>0.05), while
with or without cancerembolus formation, tumor stage were meaningful (p<0.05 ); In the non-intervention group, the age, sex, serum
HBsAg had no statistical significance, while the tumor size, tumor gross type, with or without cancerembolus formation, and tumor stage
were meaningful; In three-year survival period in the intervention group, indexes above had no statistical significance, but in the
intervention group, tumor size, with or without cancerembolus formation, and tumor stage had statistical meaning. Conclusion: Giving
positive TACE treatment to patients whose tumor are bigger than 5cm and are proved poorly differentiated by postoperative pathology
can significantly improve their recent survival rate. |
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