| 杨明娟刘海强郭娟张琰君曾丽华郭国祯.电磁脉冲(EMP)辐照对雄性子代大鼠下丘脑GABAA 受体表达的影响[J].现代生物医学进展英文版,2011,11(7):1257-1260. |
| 电磁脉冲(EMP)辐照对雄性子代大鼠下丘脑GABAA 受体表达的影响 |
| Effects of Electromagnetic Pulse on the Expression of GABAA Receptorin Hypothalamus of Male Offsprings of Rats |
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| DOI： |
| 中文关键词: 电磁脉冲 雄性大鼠 子代 GABAA 受体 |
| 英文关键词: Electromagnetic pulse Male rat Offspring GABAA receptor |
| 基金项目:国家自然科学基金(No:60971055; No: 60871068) 和国际合作项目(No: 2010DFA31900) |
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| 中文摘要: |
| 目的：观察电磁脉冲(EMP)辐照亲代大鼠后其雄性子代下丘脑GABAA 受体表达的变化。方法：应用免疫组织化学及图像分
析观察亲代大鼠接受EMP 辐照后其雄性子代下丘脑GABAA 受体表达的变化。结果：与对照组相比，100 次脉冲组其雄性子代下
丘脑室旁核GABAA 受体阳性神经元增加，400 次脉冲组光密度值显著增强；100 次和400 次脉冲组弓状核GABAA 受体阳性神经
元增加，光密度值增强。结论：电磁脉冲可以影响雄性子代下丘脑GABAA 受体的表达，这可能与电磁脉冲辐射产生的远期遗传毒
性有关。 |
| 英文摘要: |
| Objective: To investigate the relationship between the expression of GABAA receptor in hypothalamus of the offspring
of male rats and electromagnetic pulse (EMP). Methods: Immunocytochemistry combined with computer imaging analysis was carried
out to examine the expression of the GABAA receptor in hypothalamus of male offspring. Results: Compared with the rats of control
group, the expression of GABAA receptor increased in male offspring of 100 pulses group, the value of IOD increased in 400 pulses
group; The expression of GABAA receptor in the arcuate nucleus increased. Conclusions: Electromagnetic pulse could induce the
expression of GABAA receptor in hypothalamus of male offspring, which may be related to the long-term genetic toxicity of EMP. |
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