| 严俊1 陶文照2 陈伟1 卢国锋3 胡育新1.氢氧化钠瘤内注射通过抗血管生成作用抑制肝癌生长的机制研究[J].现代生物医学进展英文版,2011,11(7):1253-1256. |
| 氢氧化钠瘤内注射通过抗血管生成作用抑制肝癌生长的机制研究 |
| Effect of Intratumoral Injection of Sodium Hydroxide in Inhibitionof Liver Tumor Growth |
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| DOI： |
| 中文关键词: 原发性肝癌 瘤内注射 氢氧化钠 抗血管生成 |
| 英文关键词: Hepatocellular carcinoma Intratumoral injection Sodium hydroxide Anti-angiogenic |
| 基金项目:上海市嘉定区科学技术委员会课题（2006JKK025） |
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| 中文摘要: |
| 目的：研究氢氧化钠溶液瘤内注射对肝癌的生长抑制作用并探索其机制。方法：对SMMU-LTNM 肝癌裸鼠皮下模型进行
2%浓度的氢氧化钠溶液瘤内注射，检测肿瘤组织微血管密度、HIF-1α 和VEGF 的表达情况。结果：与生理盐水瘤内注射组相比，
氢氧化钠显著抑制肿瘤生长（P<0.01）、降低肿瘤微血管密度（P=0.01）、抑制肿瘤组织HIF-1α 和VEGF 的表达（P=0.02 和P=0.
01）。结论：氢氧化钠瘤内注射可有效抑制肝癌生长，主要机制可能是抗血管生成作用。 |
| 英文摘要: |
| Objective: To investigate the effects of intratumoral injection of sodium hydroxide on the hepatocellular carcinoma and
to investigate the mechanism. Methods: Nude mice bearing subcutaneous SMMU-LTNM tumors were given intratumoral injection with
2% sodium hydroxide or normal saline groups (n = 10 for each group). The inhibitive effects on tumor growth and tumor microvessel
density, HIF-1α and VEGF expression were detected. Results: Sodium hydroxide could significantly inhibit tumor growth (P<0.01).
Microvessel density was significantly lower in the sodium hydroxide group (P=0.01), and the expression of HIF-1α and VEGF was suppressed
(P=0.02 and P=0.01, respectively). Conclusion: Intratumoral injection with sodium hydroxide could effectively inhibit tumor
growth, the main mechanism of which may be the anti-angiogenic effects. |
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