| 刘修波卫红军张巍巍王青.IL-6、IL-23 在肠易激综合征患者肠黏膜的表达及意义[J].现代生物医学进展英文版,2011,11(7):1250-1252. |
| IL-6、IL-23 在肠易激综合征患者肠黏膜的表达及意义 |
| Expression of IL-6 and IL-23 in Bowel Mucosa of Patients with IrritableBowel Syndrome |
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| DOI： |
| 中文关键词: 肠易激综合征 细胞因子 白介素 |
| 英文关键词: Irritable Bowel Syndrome Cytokines Interleukin |
| 基金项目: |
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| 中文摘要: |
| 目的：研究肠易激综合征(irritable bowel syndrome, IBS)患者回肠末端及升结肠黏膜组织中白介素-6（interleukin-6, IL-6）、白
介素-23（interleukin-23, IL-23）的表达。方法：70 例腹泻型和40 例便秘型IBS 患者及30 例健康人，用免疫组化法测定回肠末端及
升结肠肠黏膜中IL-6 及IL-23 水平。结果：IL-6 及IL-23 在腹泻型及便秘型IBS 患者回肠末端及升结肠的表达均高于对照组
（P<0.05）。结论：IBS 患者回肠及升结肠黏膜炎性细胞因子表达水平升高，可能与IBS 症状有关。 |
| 英文摘要: |
| Objective: To study expression of interleukin (IL)-6 and IL-23 in the mucosa of ileum as well as in the ascending
colon. Methods: The ileum and ascending colon from 70 cases of diarrhea type of IBS, 40 cases of constipation group type of IBS and 30
cases of healthy volunteers as control were collected and detected the IL-6 and IL-23 expression using immunohistochemistry. Results:
Both diarrhea group and constipation group, IL-6 and IL-23 were highly expressed in the mucosa of ileum and ascending colon than control
group (P<0.05）. Conclusion: The highly expression of IL-6 and IL-23 in the mucosa of ileum and ascending colon may be related to
symptoms of IBS. |
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