| 衣丹1 林学政1 沈继红1 刘发义1 梁晓芳2.共轭亚油酸降血脂及抗动脉粥样硬化作用的研究[J].现代生物医学进展英文版,2011,11(7):1228-1230. |
| 共轭亚油酸降血脂及抗动脉粥样硬化作用的研究 |
| Effect of Conjugated Linoleic Acid in Lowering Blood Lipidsand Anti-atherosclerosis |
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| DOI： |
| 中文关键词: 共轭亚油酸 高脂血症 动脉粥样硬化 |
| 英文关键词: Conjugated linoleic acid Hyperlipoidemia Atherosclerosis |
| 基金项目:国家高技术研究发展计划"863" 资助课题(No. 2007AA091905) |
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| 中文摘要: |
| 目的：探讨共轭亚油酸降血脂及抗动脉粥样硬化形成的作用机制。方法：选用大鼠随机分为正常对照组，高脂模型组，c9,
t11CLA:t10,c12CLA=2:1、1:1、1:3、1:6，只含t10,c12CLA 共7 组。实验至第8 周末取血，检测血清胆固醇(TC)、三酰甘油(TG)、高密
度脂蛋白(HDL)、低密度脂蛋白(LDL)和丙二醛(MDA)、超氧化物歧化酶(SOD)活性。结果：与高脂模型组比较，共轭亚油酸组大鼠
血清TC、TG、MDA 含量明显降低，HDL、SOD 含量明显提高(P<0.05)。结论：共轭亚油酸具有降低血脂和抗动脉粥样硬化的作用。
关键词：共轭亚油酸；高脂血症；动脉粥样硬化 |
| 英文摘要: |
| Objective: To investigate the mechanism of hyperlipoidemia andanti-atherosclerosis effects by conjugated linoleic
acid. Methods: Rats were randomly divided into 7 groups: normal control group, hyperlipidemia model group, c9, t11CLA:t10,
c12CLA=2:1, 1:1, 1:3, 1:6, only t10, c12CLA group. 8 week after the experiment, the total cholesterol(TC), triglyceride(TG), low density
lipoprotein(LDL), high density lipoprotein(HDL), SOD and MDA in sera were detected. Results: Compared with those in the hyperlipidemia
model rats, the levels of MDA and TC, TG in the sera of rats given with CLA were lower (P<0.05), while the activity of SOD and
level of HDL increased (P<0.05). Conclusions: Conjugated linoleic acid could inhibit the hyperlipidemia and prevent the formation of
atherosclerosis. |
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