| 巴红珍徐海峰△ 周飞华魏龙晓王俊燕.甲亢甲低患者肝纤维化指标检测的临床意义分析[J].现代生物医学进展英文版,2011,11(6):1152-1154. |
| 甲亢甲低患者肝纤维化指标检测的临床意义分析 |
| Changes of Hepatofibrosis Markers in Hyperthyroidism and Hypothyroidism |
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| DOI： |
| 中文关键词: 甲亢 甲低 肝纤维化指标 |
| 英文关键词: Hyperthyroidism Hypothyroidism Hepatofibrosis index |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨甲状腺功能亢进(甲亢)、甲状腺功能减低(甲低)与肝纤维化指标的关系及其可能的机制。方法：采用放射免疫分析
法(R1A)检测57 例甲亢患者、43 例甲低患者、39 例甲亢治疗后甲状腺激素正常者和50 例健康成人的血清Ⅳ型胶原(1V-C)、Ⅲ型
前胶原(PCⅢ)、透明质酸(HA)、层粘连蛋白(LN)、T3、T4、FT3、FT4 、TSH、TGA、TMA 含量。结果：甲亢患者组血清中1V-C、PCⅢ含
量比正常对照组及甲低患者组显著性增高( P<0.05)；治疗后甲状腺激素下降，1V-C、PCⅢ含量也随之下降(与治疗前比较P<0.01
)；HA、LN 在四组中无显著性差异( P>0.05 )，在甲亢治疗前后无显著性差异( P>0.05)。各项肝纤维化指标与TGA、TMA 的阳性率
无关。结论：甲亢患者可有不同程度的肝功能损害，血清中甲状腺激素水平增高时，1V-C、PCⅢ水平也增高，在用1V-C、PCⅢ判断
肝纤维化时应注意有无甲状腺疾病特别是甲亢。未发现HA、LN 含量与甲状腺激素水平的关系。 |
| 英文摘要: |
| Objective: To study the changes of hepatofbrosis markers in hyperthyroidism and hypothyroidism. Methods: The indicatols
of thyroid function(TT3, TT4, FT3, FT4, TSH, TGA, TMA) and hepatofibrosis markers(IV-C, PCⅢ, HA, LN) were assayed with
RIA in 57 patients with hyperthyroidism, 43 patients with hypothyroidism, 39 euthyroid patients after hyperthyroidism treated and 50
controls. Results: The serum IV-C and PCⅢ levels in hype rthyroid patients were significantly higher than those in controls and hypothyroid
patients(P<0.01). In the euthyroid subjects after successful treatment, the IV-C and PCⅢ levels dropped markedly(VS before treatment,
P<0.01). However, there were no significant differences among the serum HA, LN levels in all the subjects tested. Conclusion:
Serum levels of IV -C and PCⅢ increased markedly during hyperthyroidism. When IV-C and PCⅢ levels were taken for judgment of
degree of hepatofibrosis, hyperthyroidism must be ruled out first. The HA and LN levels were not related to the status of thyroid function. |
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