欢迎访问《现代生物医学进展》编辑部！

目的：分析成都地区中老年居民血清尿酸水平及其影响因素，为防治心脑血管事件提供策略支持。方法：利用2007 代谢综合征研究调查资料（共1061 人）,把人群依据血尿酸水平分为增高组（男性＞420umol/L,女性＞357umol/L）及正常组（男性≤420umol/L, 女性≤357umol/L），分析两组人群的多个代谢性指标的分布特征，并采用logistic 回归分析寻找与尿酸相关的危险因素。结果：① 两个分组间年龄、收缩压、男性比重、高血压家族史、人体质量指数、腰围、臀围、空腹血糖、肾功能等指标尿酸增高组明显高于尿酸正常组，舒张压则是尿酸增高组明显低于尿酸正常组。② 血脂各成分中，总胆固醇、低密度脂蛋白水平尿酸增高组高于正常组，其余甘油三酯、高密度脂蛋白分组间无统计学差异。③尿酸增高组其代谢综合征、高血压、糖尿病、肥胖、腹型肥胖、血脂异常等患病率皆高于尿酸正常组，差异有统计学意义。④Logistic 回归分析提示尿酸与你男性性别、年龄、收缩压、BMI、腰围、臀围、空腹血糖、肌酐、总胆固醇、低密度脂蛋白水平呈正相关，与女性性别及舒张压呈负相关。结论：成都地区尿酸与代谢性指标及肾功能相关指标关系密切，可能可以通过减少尿酸来减少心脑血管疾病、代谢性疾病及肾脏疾病的发生。

英文摘要:

Objective: To evaluate the influencing factors on serum uric acid (SUA) among middle and aged residents in Chengdu, and to provide scientific basis for developing better intervention strategies for cardiovascular disease in Chengdu. Methods: We divide the 1061 middle and aged people into 2 groups, who came from the survey for metabolic syndrome study in 2007. They are normal SUA group and HUA group. The normal group means the SUA of the people is less than or equal to 420 umol/L for male, and 357 umol/L for female. The HUA group is SUA more than 420 umol/L for male and 357 umol/L. We analyze the distribution of risk factors relate to SUA. Results: ① The indices of age, the proportion of men, systolic blood pressure (SBP), the rate of positive history of hypertension, Body mass index(BMI), waist circumference(WC), hip circumference(HC), fasting blood glucose(FBG), creatinine(CA) and uric acid (UA) in augmented PP/PPI group are higher than those in normal group, and the difference between the two groups is statistically significant. As to diastolic blood pressure(DBP), the normal group is statistically higher than that in HUA group. ② TC and LDL in HUA group are statistically higher than those in normal group. And there is no statistically difference between 2 groups on TG and HDL. ③ The prevalences of metabolic syndrome, hypertension, diabetes mellitus, obesity, abdominal obesity and Dyslipidemia in HUA group are all statistically higher than those in normal group. ④ SUA was positively related to male, age, SBP, BMI, WC, HC, FBG, creatinine, uric acid, TC, and LDL by using logistic regression analysis, and they are negatively related to female and DBP. Conclusions: The SUA is closely related to the metabolic indices and renal index in Chengdu. It might be a feasible way to reduce the incidence and development of cardiovascular disease and kidney disease by maintaining SUA within an appropriate range.

View Full Text View/Add Comment Download reader