| 耿玉荣1 赵雯2 古丽松3 谢靖1 余娟1 梁华锋1 王宏1.新疆哈萨克族脑梗塞与ICAM-1 基因G241R 多态性的关系[J].现代生物医学进展英文版,2011,11(6):1093-1096. |
| 新疆哈萨克族脑梗塞与ICAM-1 基因G241R 多态性的关系 |
| The Relationship Between ICAM-1 Gene G241R Polymorphism andCerebral Infarction in Xinjiang Kazakans |
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| DOI： |
| 中文关键词: 酸性ICAM-1 基因 多态性 脑梗塞 |
| 英文关键词: ICAM-1 Gene Polymorphism cerebral infarction |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨新疆哈萨克族脑梗死与细胞黏附分子1(ICAM-1)G241R 基因多态性的关系。方法：采用多聚酶链式反应法及限制
性内切酶片段长度多态性技术，对新疆哈萨克族100 例脑梗死患者及110 例健康者（对照组）进行ICAM-1 基因G241R 多态性检
测，比较不同基因型与哈萨克族脑梗塞发病风险的关系。结果：脑梗塞患者ICAM-1 基因G41R 多态性的基因型频率和等位基因
频率与健康对照组相比无明显差异。结论：ICAM-1 基因G214R 多态性可能不是新疆哈萨克族脑梗塞发病的遗传学危险因素。 |
| 英文摘要: |
| Objective: To investigate the relationship between the polymorphism of ICAM-1 gene K241R and cerebral infarction
in Kazakans of Xinjiang. Methods: RePolymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods
were used to detect the G241R polymorphism of ICAM-1 gene in Kazakans including 100 patients with cerebral infarction and 110
healthy individuals (control group). The frequencies of genotype and allele and the association between the genetic polymorphisms and
cerebral infarction were analyzed. Results: The prevalence rates of genotype and allele frequency of ICAM-1 gene G241R polymorphism
are not significantly different between cerebral infarction and contron group (P>0.05). Conclusion: ICAM-1 gene G241R polymorphism
is not associated with cerebral infarction in Kazakans of Xinjiang. |
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