| 吴珊珊1 赵海波2 武雁2 张建芳2 陈必良1.褪黑素对小鼠2- 细胞期胚胎发育的影响[J].现代生物医学进展英文版,2011,11(6):1072-1074. |
| 褪黑素对小鼠2- 细胞期胚胎发育的影响 |
| Effect of melatonin on development of mice 2-cell embryos |
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| DOI： |
| 中文关键词: 褪黑素 2- 细胞胚胎 体外胚胎发育 小鼠 |
| 英文关键词: Melatonin Two-cell embryo In vitro development Mouse |
| 基金项目: |
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| 中文摘要: |
| 目的：研究褪黑素对小鼠2- 细胞期胚胎发育的影响。方法：在培养液中添加不同浓度褪黑素，在不同的作用时间点，观察并
记录小鼠胚胎囊胚率、孵出率，研究其变化情况。结果：不同浓度褪黑素对小鼠2- 细胞期胚胎存在双向作用，在10-13-10-5M 之间促
进细胞囊胚形成和孵出，在10-9M 时促进效应达到最高，而在10-3M 时则呈现出一定的毒性作用。结论：褪黑素对小鼠胚胎发育影
响与褪黑素浓度密切相关。 |
| 英文摘要: |
| Objective: To investigate the effects of melatonin on the development of mice 2-cell embryos. Methods: The effects of
various concentrations of melatonin （10-13-10-3M）on the development of mouse embryos were detected. The blastocyst rate and hatching
rate of mouse embryos were recorded after treated by different concentrations of melatonin. Results: Melatonin could improve the development
of mice 2-cell embryo in a bi-phasic manner. The rates of blastocyst formation and hatched blastocysts increased by melatonin at
10-13-10-5M, and the maximum effects arrived at 10-9M. However, the toxic effects appeared at 10-3M. Conclusions: Melatonin affect the
development of mice embryos depending the concentrations of melatonin. |
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