| 张淑鹏1,2 李琳琳1 木合布力·阿布力孜1 王丽凤3 景兆均4 毛新民2,3.昆仑雪菊提取物对α- 葡萄糖苷酶的抑制作用[J].现代生物医学进展英文版,2011,11(6):1055-1058. |
| 昆仑雪菊提取物对α- 葡萄糖苷酶的抑制作用 |
| Inhibition of Extracts of Coreopsis Tinctoria Flowers from KunlunMountain on α-Glucosidase |
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| DOI： |
| 中文关键词: 昆仑雪菊 α- 葡萄糖苷酶 抑制活性 |
| 英文关键词: Coreopsis tinctoria flowers α-Glucosidase Inhibitory activity |
| 基金项目:自治区重点实验室开放课题基金（XJDX0208-2008-06） |
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| 中文摘要: |
| 目的：探讨昆仑雪菊提取物对α- 葡萄糖苷酶的抑制活性。方法：将昆仑雪菊干燥花序粉碎, 分别用水提法和乙醇法制备5
种提取物。采用α- 葡萄糖苷酶体外活性抑制模型, 测定昆仑雪菊的5 种提取物对α- 葡萄糖苷酶的抑制活性。结果：这5 种提取
物对α- 葡萄糖苷酶活性有较强的抑制作用，抑制活性均高于阿卡波糖。其中提取物Ⅰ的抑制活性最强，IC50 =28.2 mg/L。结论：
昆仑雪菊提取物具有较高的α- 葡萄糖苷酶抑制活性，提示昆仑雪菊在抗糖尿病产品开发方面具有很好的应用前景。 |
| 英文摘要: |
| Objective: To investigate the inhibited effect of Coreopsis tinctoria flowers extracts from the Kunlun Mountain on
alpha-glycosidase. Methods: The dry inflorescence of Coreopsis tinctoria flowers wre crushed, and then five extracts with water and alcohol
extraction were prepared, respectively. The inhibitory activity on alpha-glycosidase of the five extracts of Coreopsis tinctoria flowers
were identified by vitro activity inhibition models of alpha-glycosidase. Results: The five extracts have higher inhibition activity on
alpha-glycosidase than acarbose. Among them, the extract Ⅰ had the most inhibited effect with IC50=28.2mg/L. Conclusion: The extracts
have inhibited effect on alpha-glycosidase, which indicated Coreopsis tinctoria flowers had good application prospects in antidiabetic
product development. |
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