| 曹鹏冲1 雷伟1△ 高雁翎2 颉强1 程欢1 刘帅1.藏红花提取液对去卵巢大鼠骨密度及骨代谢生化指标的影响[J].现代生物医学进展英文版,2011,11(6):1009-1012. |
| 藏红花提取液对去卵巢大鼠骨密度及骨代谢生化指标的影响 |
| Effects of Crocus Sativus Extract on Bone Mineral Density and BiochemistryMarkers of Bone Metabolism in Ovariectomized Rats |
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| DOI： |
| 中文关键词: 藏红花 骨质疏松 骨密度 雌二醇 碱性磷酸酶 |
| 英文关键词: Crocus sativus Osteoporosis BMD Estrogen Bone metabolism |
| 基金项目:国家863 基金项目" 骨质疏松条件下提高脊柱内固定强度的整体解决方案"（2007AA02Z468） |
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| 中文摘要: |
| 目的：研究中药藏红花提取液对去卵巢大鼠股骨骨密度及血清骨代谢生化指标的影响。方法：选用48 只4 月龄SD 雌性大
鼠，随机分为6 组：假手术组、模型组、戊酸雌二醇组、藏红花低、中、高剂量组。术后4 周各组分别给予相应制剂灌胃，术后12 周
处死，分别测定股骨骨密度、子宫指数、雌二醇、血钙、血磷、碱性磷酸酶。结果：与模型组相比，藏红花各剂量组股骨骨密度明显升
高（p<0.01），雌二醇测定值升高（p<0.01），碱性磷酸酶显著降低（p<0.01），血钙及血磷无统计学差异（p>0.05）；与戊酸雌二醇组比
较，藏红花各剂量组子宫指数显著降低（p<0.01）。结论：藏红花提取液有助于抑制去卵巢大鼠骨量的丢失，改善骨代谢，对骨质疏
松症具有防治作用。 |
| 英文摘要: |
| Objective: To investigate the effects of Crocus sativus extraction on bone mineral density (BMD) and biochemistry
markers of bone metabolism in ovariectomized rats. Methods: Forty-eight female Sprague-dawley rats, four months old, were randomly
divided into six groups: the sham-operating group (Sham), the ovarictomized group (OVX), estradiol valerate treated group (E2),
low-dose of Crocus sativus treated group (L-Crocus), medium-dose of Crocus sativus treated group (M-Crocus) and high-dose of Crocus
sativus treated group (H-Crocus). Four weeks after surgery, the rats of Sham group and OVX group were intra-gastric administrated with
distilled water, while the rats of the E2 group received estradiol valerate (0.8mg/kg.d) and rats of other three groups received different
dosage of Crocus sativus extract (25, 50, 100mg/kg.d) by gavage for 8 weeks. Then all the rats were executed and their right femoral
bones and blood sera were collected. The BMD, index of uterus, serum estrogen levels and serum biochemical markers of bone
metabolism were determined. Results: The BMD and serum estrogen levels in the rats of three Crocus sativus extract treated groups were
significantly higher than that in OVX group （p<0.01）, while the serum alkaline phosphatase (ALP) level in the former were obviously
lower than that in the latter（p<0.01）. Compared with the E2 group, the index of uterus decreased significantly in three Crocus sativus
extract treated groups (p<0.01). Conclusion: Crocus sativus showed the potential effects on prevention of osteoporosis in ovariectomized
rats by inhibiting the bone mineral loss and improving the bone metabolism. |
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