| 张焕莉肖新华.脂肪细胞因子锌α2- 糖蛋白的研究进展[J].现代生物医学进展英文版,2011,11(5):946-948. |
| 脂肪细胞因子锌α2- 糖蛋白的研究进展 |
| Current progress in a adipocytokine-zinc-α2-glycoprotein |
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| DOI： |
| 中文关键词: 锌α2- 糖蛋白 生物标志物 肥胖 脂质动员因子 |
| 英文关键词: Zinc-α2-glycoprotein Biomarker Obesity Lipid mobilizing adipokine |
| 基金项目:国家自然科学基金（81070667） |
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| 中文摘要: |
| 锌α2- 糖蛋白（ZAG）是一种广泛存在于人体内的可溶性糖蛋白，是Ι类主要组织相容性复合物(MHC-Ι）家族中的一员。
ZAG 被认为是不同类型癌可能的生物标志物，由于它的氨基酸序列与脂质动员因子（LMF）高度同源，因此它被认为是一个新的
脂肪因子。它的表达受多种因素调控，在人体内能够发挥重要的功能。ZAG 刺激脂肪细胞的脂质分解，并导致一些高分化癌症中
脂肪的大量损失。本文主要从ZAG 的基因结构、分布和功能等方面进行论述。 |
| 英文摘要: |
| Zinc-α2-glycoprotein (ZAG) is a soluble glycoprotein, present widely in the human body, is a member of the class I
major histocompatibility complex family. ZAG is considered as a potential biomarkers of different types of carcinomas .Due to its high
homology of amino acid sequence with lipid mobilization factor, it is considered as a novel adipokine. ZAG expression is regulated by
different types of factors ,can play important functions in the human body.ZAG stimulates lipid degradation in adipocytes and causes the
extensive fat losses associated with some advanced cancers.This article will discuss mostly knowledge on the ZAG gene structure,
distribution and function. |
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