| 王蕾1 崔竹梅1 郑烨1 刘芝华2 颜丽丽1.SPARC 在子宫内膜癌组织中的表达及意义[J].现代生物医学进展英文版,2011,11(5):905-908. |
| SPARC 在子宫内膜癌组织中的表达及意义 |
| Expression and Significance of the SPARC Protein in EndometrialCarcinoma |
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| DOI： |
| 中文关键词: 富含半胱氨酸的酸性分泌型蛋白（SPARC） 子宫内膜癌 组织芯片 |
| 英文关键词: Secreted protein acidic and rich in cysteine(SPARC) Endometrial carcinoma Tissue microarray |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨富含半胱氨酸的酸性分泌型蛋白( secreted protien ,acidic and rich in cysteine，SPARC) 在子宫内膜癌组织中的表
达及其临床意义。方法：应用组织芯片技术研究SPARC 在正常子宫内膜、增生的子宫内膜和子宫内膜癌组织中的表达情况。结
果：SPARC 在正常子宫内膜、增生的子宫内膜和子宫内膜癌组织中的阳性表达率分别为96.55 %、76.79 %、59.50 %,差异具有统
计学意义（P< 0.05)。在子宫内膜癌中，SPARC 的表达强度与手术- 病理分期、组织学分级、肌层浸润深度和淋巴结转移相关，差异
具有统计学意义（P< 0.05)。结论：SPARC 表达的缺失与子宫内膜癌的发生、发展密切相关，检测SPARC 可为子宫内膜癌的早期
诊断、进一步治疗及预后判断提供一定的理论依据。 |
| 英文摘要: |
| Objective: To investigate the expression of secreted protein acidic and rich in cysteine (SPARC) in endometrial
carcinoma. Methods: The expressions of SPARC in normal endometrium, proliferetive endometrium and endometrial carcinoma were
analyzed by tissue microarray technique. Results: The positive rate of SPARC protein expression was 96.55 %, 76.79 %, 59.50 % in
normal endometrium, proliferetive endometrium and endometrial carcinoma, respectively, which had statistical significance obviously
compared with other groups (P＜0.05). In endometrial carcinoma, the expression of SPARC was related to surgical stage, histological
grade, myometrial invasion and lymph node metastasis, with a statistical significance ( P < 0.05). Conclusions: The expression loss of
SPARC protein was related with the generation and development of endometrial carcinoma. Detection of SPARC may provide a certain
theory for the early diagnosis, further treatment and prognosis of endometrial carcinoma. |
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