| 付建芳1 涂艳阳2 付菊芳3 高彬1 王莉1 邢影1 翟文松1 赵昕1 姬秋和1.糖耐量减低患者血清瘦素与内皮素-1 的测定及其临床意义[J].现代生物医学进展英文版,2011,11(5):902-904. |
| 糖耐量减低患者血清瘦素与内皮素-1 的测定及其临床意义 |
| The significance of serum level of Leptin and ET-1 in patients withimpaired glucose toleranc |
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| DOI： |
| 中文关键词: 糖耐量减低 瘦素 内皮素 |
| 英文关键词: Impaired glucose toleranc Leptin ET-1 |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨糖耐量减低(IGT)患者血清瘦素(Leptin)和血浆内皮素-1(ET-1)含量变化及其意义。方法：采用放射免疫法检测65
例IGT 患者、50 名正常健康体检者和50 例2 型糖尿病患者血清中Leptin 和ET-1 的含量，同时分别测定体重指数、腰臀比、空腹
血糖(FBG)、餐后2 小时血糖(2h PBG)及空腹胰岛素(FINS)，并用HOMA 稳态模型计算胰岛素抵抗指数(HOMA-IR)。结果：糖尿病
组、IGT 组血清Leptin、ET-1、FBG、2hPBG、FINS、TC 含量及HOMA-IR 指数显著高于正常对照组(P<0.05)，糖尿病组血清Leptin、
ET-1、FBG、2hPBG、FINS、TC 含量及HOMA-IR 指数明显高于IGT 组(P<0.05)。IGT 组血清Leptin 水平与BMI、血清ET-1、FBG、
2hPBG、FINS、TC 含量及HOMA-IR 指数呈显著正相关(P<0.01)，IGT 组血清ET-1 水平与收缩压、舒张压、BMI、血清FBG、
2hPBG、FINS 含量及HOMA-IR 指数呈显著正相关(P<0.01)。结论：瘦素与内皮素-1 均可能在IGT 发展成2 型糖尿病过程中起一
定的作用。 |
| 英文摘要: |
| Objective: To investigate the significance of serum level of Leptin and ET-1 in patients with impaired glucose toleranc
(IGT). Methods: Serum level of Leptin and ET-1 in 65 patients with IGT，50 subjects with healthy people，and 50 patients with type 2
diabetes mellitus (DM)were detected by ELISA．Body mass index (BMI), WHR, FBG , 2h PBG and FINS were detected. The insulin
resistance by homeostasis model assessment (HOMA-IR) was calculated. Results: Serum level of Leptin, ET-1, FBG,2hPBG,FINS,TC
and HOMA-IR in DM group and IGT group were higher than those in the control group. Serum level of Leptin, ET-1, FBG, 2hPBG,
FINS, TC and HOMA-IR in DM group were higher than those in IGT group. Serum level of Leptin in IGT group were correlated with
BMI, while the serum level of ET-1,FBG,2hPBG,FINS,TC and HOMA-IR. Serum level of ET-1 in IGT group were correlated with SBP,
DBP,BMI, serum level of FBG,2hPBG,FINS and HOMA-IR. Conclusions: Serum level of Leptin and ET-1 may play a role in the
pathogenesis from IGT to type 2 diabetes. |
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