Article Summary
张慧敏丘文君黎青孙筱放.1200 例孕中期产前筛查结果的回顾性分析[J].现代生物医学进展英文版,2011,11(5):893-895.
1200 例孕中期产前筛查结果的回顾性分析
Prenatal Screening in Mid-PregnancyWomen: Analysis of 1200 Cases
  
DOI:
中文关键词: 唐氏综合征  出生缺陷  产前筛查
英文关键词: Down's syndrome  Birth defect  Prenatal screening
基金项目:广州市科技攻关重大项目课题(2004E1-E0013)
Author NameAffiliation
ZHANG Hui-min, QIU Wen-jun, LI Qing, SUN Xiao-fang 广州医学院第三附属医院妇产科 
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中文摘要:
      目的:评价孕妇血清标记物(甲胎蛋白AFP、β- 绒毛膜促性腺激素β-hCG 和雌三醇uE3) 的孕中期三联筛查在临床中的应用 价值。方法:采用酶联免疫吸附法(ELISA)对1200 例孕中期(14~22 周)孕妇进行血清标记物AFP、β-hCG 和uE3 的检测,结合孕 龄、孕周、体重等因素,经专门的筛查分析软件,计算唐氏综合征,18 三体及神经管缺陷(NTD)的风险率。如孕妇为高风险,则进行 胎儿的超声检查和染色体核型分析的产前诊断。结果:在1200 例孕妇中,筛查高风险的孕妇有73 例,其中唐氏综合征,18 三体, NTD 高风险孕妇分别为65 例,5 例和3 例,假阳性率为6.08%(73/1200)。其中59 例接受了产前诊断,占高风险孕妇的80.8% (59/73)。共检出1 例唐氏综合征儿和1 例无脑儿,未发现18 三体,检出率为100%(2/2),未有漏诊的情况。妊娠不良结局在筛查高 风险组和低风险组的比率分别为17.1%和1.32%,两组有显著性差异(P<0.01)。结论:利用孕妇血清标记物(AFP、β-hCG 和uE3)的 孕中期无创伤性产前筛查,结合产前诊断,对减少出生缺陷儿的出生,具有重要意义,并且高风险的筛查结果对胎儿的预后有一 定的提示作用。
英文摘要:
      Objective: To assess the value of triple test with three maternal serum markers:α-fetoprotein (AFP), free-β-human chorionic gonadotrophin (free-β-hCG)and unconjugated estriol (uE3) in the second trimester prenatal screening. Methods: Prenatal serum screening were offered to the 14~22 weeks pregnant women by measuring the serum AFP, free-βhCG and uE3 with ELISA and calculating the risk by special software. If the risk is high, the pregnant women were advised to do prenatal diagnosis. Results: Within 1 200 cases of women, the cases in high risk are 73, including 65 cases in Down's syndrom, 5 cases in 18-trisomy and 3 cases in neural tube defect. The false positive rate were 6.08% , and the detect rate were 100% (2/2). 1 case was confirmed the Down's syndrome by cytogenetics analysis, another 1 case was diagnosed the neural tube defect via ultrasonography. adverse obstetric outcome between high risk group and the low risk group were 17.1% and 1.32%, the difference was significant (P <0.01). Conclusion: The prenatal screening with maternal serum markers: AFP, Free-βhCG and uE3 is an effective and safe screening strategy, and the high risk result is helpful in obstetric outcome.
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