张慧敏丘文君黎青孙筱放.1200 例孕中期产前筛查结果的回顾性分析[J].现代生物医学进展英文版,2011,11(5):893-895. |
1200 例孕中期产前筛查结果的回顾性分析 |
Prenatal Screening in Mid-PregnancyWomen: Analysis of 1200 Cases |
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DOI: |
中文关键词: 唐氏综合征 出生缺陷 产前筛查 |
英文关键词: Down's syndrome Birth defect Prenatal screening |
基金项目:广州市科技攻关重大项目课题(2004E1-E0013) |
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中文摘要: |
目的:评价孕妇血清标记物(甲胎蛋白AFP、β- 绒毛膜促性腺激素β-hCG 和雌三醇uE3) 的孕中期三联筛查在临床中的应用
价值。方法:采用酶联免疫吸附法(ELISA)对1200 例孕中期(14~22 周)孕妇进行血清标记物AFP、β-hCG 和uE3 的检测,结合孕
龄、孕周、体重等因素,经专门的筛查分析软件,计算唐氏综合征,18 三体及神经管缺陷(NTD)的风险率。如孕妇为高风险,则进行
胎儿的超声检查和染色体核型分析的产前诊断。结果:在1200 例孕妇中,筛查高风险的孕妇有73 例,其中唐氏综合征,18 三体,
NTD 高风险孕妇分别为65 例,5 例和3 例,假阳性率为6.08%(73/1200)。其中59 例接受了产前诊断,占高风险孕妇的80.8%
(59/73)。共检出1 例唐氏综合征儿和1 例无脑儿,未发现18 三体,检出率为100%(2/2),未有漏诊的情况。妊娠不良结局在筛查高
风险组和低风险组的比率分别为17.1%和1.32%,两组有显著性差异(P<0.01)。结论:利用孕妇血清标记物(AFP、β-hCG 和uE3)的
孕中期无创伤性产前筛查,结合产前诊断,对减少出生缺陷儿的出生,具有重要意义,并且高风险的筛查结果对胎儿的预后有一
定的提示作用。 |
英文摘要: |
Objective: To assess the value of triple test with three maternal serum markers:α-fetoprotein (AFP), free-β-human
chorionic gonadotrophin (free-β-hCG)and unconjugated estriol (uE3) in the second trimester prenatal screening. Methods: Prenatal
serum screening were offered to the 14~22 weeks pregnant women by measuring the serum AFP, free-βhCG and uE3 with ELISA and
calculating the risk by special software. If the risk is high, the pregnant women were advised to do prenatal diagnosis. Results: Within 1
200 cases of women, the cases in high risk are 73, including 65 cases in Down's syndrom, 5 cases in 18-trisomy and 3 cases in neural tube
defect. The false positive rate were 6.08% , and the detect rate were 100% (2/2). 1 case was confirmed the Down's syndrome by
cytogenetics analysis, another 1 case was diagnosed the neural tube defect via ultrasonography. adverse obstetric outcome between high
risk group and the low risk group were 17.1% and 1.32%, the difference was significant (P <0.01). Conclusion: The prenatal screening
with maternal serum markers: AFP, Free-βhCG and uE3 is an effective and safe screening strategy, and the high risk result is helpful in
obstetric outcome. |
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