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黄晓梅1 陈协群1△ 高广勋1 余芳1 肖春2.滤泡辅助性T 细胞在特发性血小板减少性紫癜患者的变化及其意义*[J].现代生物医学进展英文版,2011,11(5):827-829.
滤泡辅助性T 细胞在特发性血小板减少性紫癜患者的变化及其意义*
T Follicular Helper Cells in Peripheral Blood of Patients with ImmuneThrombocytopenic Purpura*
  
DOI:
中文关键词: 滤泡辅助性T 细胞  CXCR5  CD4  IL-21  特发性血小板减少性紫癜
英文关键词: Tfh  CXCR5  CD4  IL-21  ITP
基金项目:国家自然科学基金(C140202)
Author NameAffiliation
HUANG Xiao-mei1, CHEN Xie-qun1△, GAO Guang-xun1, YU Fang1, XIAO Chun2 第四军医大学第一附属医院血液内科 
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中文摘要:
      目的:研究滤泡辅助性T 细胞(T follicular helper cells,Tfh)在免疫性血小板减少性紫癜(immune thrombocytopenic purpura , ITP)患者的表达并探讨其临床意义。方法:用流式细胞术检测20 例健康人、25 例ITP 患者外周血CXCR5+CD4+T 细胞占CD4+ T 细胞的比例。结果:与健康对照组相比,ITP 患者外周血CXCR5+CD4+ T 细胞占CD4+ T 细胞的比例显著增高(P<0.05)。结论: Tfh 在ITP 患者外周血比例增高,为Tfh 能否为ITP 的免疫调节和干预提出新的方向提供了证据。
英文摘要:
      Objective: To investigate the expression of the T follicular helper cells (Tfh) in in peripheral blood of patients with immune thrombocytopenic purpura (ITP). Methods: 25 patients with ITP and 20 healthy adults without immunologic diseases or infectious disorders were chosen in this study.Peripheral blood was stained with anti- CD4-FITC and anti-CXCR5-PerCP. For cell surface staining, both Abs were added and cells were stained for 30 minutes. Stained cells were examined by flow cytometric. Results: The ratio of CXCR5+CD4+ T cells in ITP patients is significantly higher than that in the control group [(13.8±0.41% VS 9.6±0.30) P<0.05]. Conclusion: The ratio of Tfh increased in ITP patients. Tfh might play a role in evaluation and treatment of ITP.
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